The Evaluation of the Diagnostic Performance of the BioFire FilmArray Meningitis/Encephalitis Panel in Children: A Retrospective Multicenter Study

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dc.contributor.authorBal A.
dc.contributor.authorSaz E.U.
dc.contributor.authorArslan S.Y.
dc.contributor.authorAtik S.
dc.contributor.authorBayturan S.
dc.contributor.authorYurtseven A.
dc.contributor.authorGazi H.
dc.contributor.authorCicek C.
dc.contributor.authorKurugol Z.
dc.contributor.authorBal Z.S.
dc.date.accessioned2024-07-22T08:03:57Z
dc.date.available2024-07-22T08:03:57Z
dc.date.issued2022
dc.description.abstractObjective Acute bacterial meningitis (ABM) declined after implementing conjugate Haemophilus influenzae type B and the pneumococcal vaccines worldwide. However, it still contributes to significant morbidity and mortality. The Biofire FilmArray Meningitis Encephalitis (FAME) panel can rapidly diagnose common bacterial and viral pathogens. Several studies suggested that the use of FAME may accelerate diagnosis and decrease the time to pathogen-specific therapy. However, the clinical utility is still controversial due to scarce data and relatively high costs. Therefore, we aimed to evaluate the diagnostic performance of FAME in children. Methods A retrospective multicenter cross-sectional study was conducted to evaluate FAME in diagnosing ABM in children with a suspected central nervous system infection between January 2017 and May 2021. Results This study consisted of 179 children diagnosed with central nervous system infection who had parallel testing done using FAME and traditional microbiological diagnostic methods. Twenty-two FAME results were positive; 8 (36.3%) were bacterial pathogens and 14 (53.7%) were viral pathogens . The most common viral pathogen was human herpesvirus 6 (n = 6; 27.2%), followed by herpes simplex virus 1 (n = 4; 18.1%), Enterovirus spp. (n = 2; 9%), Parechovirus (n = 2; 9%), and Cytomegalovirus (n = 1; 4.5%). Bacterial pathogens included S. pneumoniae (n = 3; 13.6%), H. influenzae (n = 3; 13.6%), Neisseria meningitidis (n = 1; 4.5%), and Streptococcus agalactiae (n = 1; 4.5%). Bacterial culture confirmed S. pneumoniae infection in only 1 of 8 (12.5%) patients, while 7 of 8 bacterial meningitis were only detected by FAME. Conclusion FAME may also help with diagnosis and pathogen identification in patients who have already had antibiotics before cerebrospinal fluid collection. The use of FAME to detect infections quickly may minimize the improper use of medications, treatment duration, and the cost of hospitalization. © 2022. Thieme. All rights reserved.
dc.identifier.DOI-ID10.1055/s-0042-1756711
dc.identifier.issn13057707
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12498
dc.language.isoEnglish
dc.publisherGeorg Thieme Verlag
dc.subjectampicillin
dc.subjectC reactive protein
dc.subjectceftriaxone
dc.subjectgentamicin
dc.subjectglucose
dc.subjectHaemophilus influenzae type b vaccine
dc.subjectPneumococcus vaccine
dc.subjectantibiotic therapy
dc.subjectantiviral therapy
dc.subjectArticle
dc.subjectbacterial meningitis
dc.subjectbacterial virulence
dc.subjectbacterium culture
dc.subjectbehavior disorder
dc.subjectcentral nervous system infection
dc.subjectcerebrospinal fluid examination
dc.subjectchild
dc.subjectconsciousness level
dc.subjectcross-sectional study
dc.subjectCytomegalovirus
dc.subjectdemographics
dc.subjectdiagnostic procedure
dc.subjectdiagnostic test accuracy study
dc.subjectemergency ward
dc.subjectEnterovirus
dc.subjectfebrile convulsion
dc.subjectfemale
dc.subjectfever
dc.subjectfontanel
dc.subjectHaemophilus influenzae
dc.subjectheadache
dc.subjecthealth care cost
dc.subjecthospital cost
dc.subjecthuman
dc.subjectHuman alphaherpesvirus 1
dc.subjectHuman herpesvirus 6
dc.subjecthypoglycorrhachia
dc.subjectlethargy
dc.subjectleukocyte count
dc.subjectlumbar puncture
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmicrobiological examination
dc.subjectmorbidity
dc.subjectmortality
dc.subjectmulticenter study
dc.subjectnausea and vomiting
dc.subjectNeisseria meningitidis
dc.subjectnested polymerase chain reaction
dc.subjectneurologic disease
dc.subjectneutrophil count
dc.subjectnuchal rigidity
dc.subjectParechovirus
dc.subjectpediatric hospital
dc.subjectpersonality disorder
dc.subjectpleocytosis
dc.subjectprotein cerebrospinal fluid level
dc.subjectreal time polymerase chain reaction
dc.subjectretrospective study
dc.subjectseizure
dc.subjectstiff neck
dc.subjectStreptococcus agalactiae
dc.subjectStreptococcus pneumonia
dc.subjectStreptococcus pneumoniae
dc.subjecttreatment duration
dc.subjectTurkey (republic)
dc.subjectvirus encephalitis
dc.subjectvirus virulence
dc.subjectvomiting
dc.titleThe Evaluation of the Diagnostic Performance of the BioFire FilmArray Meningitis/Encephalitis Panel in Children: A Retrospective Multicenter Study
dc.typeArticle

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