The acute effects of cilazapril on pulmonary function tests and arterial blood gas changes in patients with pulmonary hypertension

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dc.contributor.authorTavli T.
dc.contributor.authorSekuri C.
dc.contributor.authorGoktalay T.
dc.contributor.authorUyanik B.S.
dc.contributor.authorAri Z.
dc.date.accessioned2024-07-22T08:24:45Z
dc.date.available2024-07-22T08:24:45Z
dc.date.issued2003
dc.description.abstractThe aim of the present study was to evaluate pulmonary function tests and arterial oxygen transport in patients with pulmonary hypertension due to congestive heart failure before and after cilazapril treatment. Thirty patients (16 men and 14 women, mean age, 65 ± 18 years) with congestive heart failure and 30 healthy volunteers (20 men and 10 women, mean age 59 ± 12 years, p > 0.05) were included in the study. All patients underwent evaluation of pulmonary function by spirometry and arterial blood gas analysis. Arterial oxygen saturation and arterial oxygen transport changed significantly after treatment (81 ± 7 to 87 ± 8 and 317 ± 74 to 392 ± 8, respectively). Forced expiration volume in 1 second, vital capacity and total lung capacity were increased after cilazapril treatment (2.55 ± 0.7 to 2.61 ± 0.8, 3.2 ± 0.9 to 3.3 ± 1.0 and 3.6 ± 0.9 to 4.1 ± 1.1, respectively, p < 0.05). In conclusion, short-term cilazapril administration improved pulmonary function and arterial oxygen transport because it increased cardiac output, produced pulmonary vasodilatation, improved the pulmonary hemodynamics and removed interstitial fluid.
dc.identifier.issn02511649
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20105
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAged
dc.subjectAngiotensin-Converting Enzyme Inhibitors
dc.subjectAntihypertensive Agents
dc.subjectArteries
dc.subjectBlood Gas Analysis
dc.subjectBlood Pressure
dc.subjectCilazapril
dc.subjectEchocardiography, Doppler
dc.subjectFemale
dc.subjectHeart Failure, Congestive
dc.subjectHemodynamic Processes
dc.subjectHumans
dc.subjectHypertension, Pulmonary
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOxygen
dc.subjectPulmonary Gas Exchange
dc.subjectStroke Volume
dc.subjectcilazapril
dc.subjectadult
dc.subjectaged
dc.subjectarterial gas
dc.subjectarterial oxygen tension
dc.subjectarticle
dc.subjectblood gas analysis
dc.subjectclinical article
dc.subjectcongestive heart failure
dc.subjectcontrolled study
dc.subjectdose response
dc.subjectfemale
dc.subjectforced expiration
dc.subjectheart output
dc.subjecthuman
dc.subjectinterstitial fluid
dc.subjectlung function
dc.subjectlung function test
dc.subjectlung hemodynamics
dc.subjectmale
dc.subjectoxygen transport
dc.subjectpulmonary hypertension
dc.subjectspirometry
dc.subjecttotal lung capacity
dc.subjecttreatment planning
dc.subjectvasodilatation
dc.subjectvital capacity
dc.titleThe acute effects of cilazapril on pulmonary function tests and arterial blood gas changes in patients with pulmonary hypertension
dc.typeArticle

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