Serum hypoxia-inducible factor-2: A candidate prognostic biomarker for laryngeal cancer
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Date
2021
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Abstract
Objectives: To determine the serum hypoxia-inducible factor-1, -2 and -3 (HIF-1, -2 and -3) levels in patients with laryngeal neoplasm, and to investigate their role in differential diagnosis, prediction of tumour characteristic and extension, and prognosis and survival. Study Design: Prospective, cohort study at a tertiary referral centre. Settings: The study was conducted in a tertiary medical centre. Participants: Patients with benign, premalignant and malignant laryngeal neoplasms were included. Sixty-four patients with a laryngeal neoplasm were enrolled. Main Outcome Measures: Serum HIF-1, -2 and -3 levels were measured from blood samples that were drawn before treatment, using ELISA. Results: A statistically significant difference between benign (HIF-1, -2, -3:4046,1 pg/mL; 2581,5 pg/mL; 1321,0 pg/mL), premalignant (HIF-1, -2, -3:3630,3 pg/mL; 3229,7 pg/mL; 2549,8 pg/mL) and malignant (HIF-1, -2, -3:3576,7 pg/mL; 2595,8 pg/mL; 1106,3 pg/mL) laryngeal neoplasms was not detected when serum HIF-1, -2 and -3 levels were compared. However, high serum HIF-2 level adversely affected survival and locoregional control and had more than 7-fold increase in hazard ratio. Moreover, serum HIF-2 was an independent prognostic factor for 2-year overall, disease-free, distant metastasis-free survival and locoregional control. Conclusion: This is the first clinical study in which the diagnostic, predictive and prognostic roles of hypoxia-related biomolecules were examined in laryngeal neoplasms. Hypoxia-inducible factor-2 is a prognostic factor in larynx cancer irrespective of treatment modality. © 2021 John Wiley & Sons Ltd.
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Adult , Aged , Aged, 80 and over , Basic Helix-Loop-Helix Transcription Factors , Biomarkers, Tumor , Cohort Studies , Disease-Free Survival , Female , Humans , Hypoxia , Laryngeal Neoplasms , Male , Middle Aged , Prognosis , Prospective Studies , hypoxia inducible factor , hypoxia inducible factor 1 , hypoxia inducible factor 2 , hypoxia inducible factor 3 , tumor marker , unclassified drug , basic helix loop helix transcription factor , tumor marker , adult , anemia , Article , cancer prognosis , cancer survival , clinical feature , diagnostic value , differential diagnosis , disease association , disease free survival , distant metastasis free survival , enzyme linked immunosorbent assay , female , human , larynx cancer , major clinical study , male , overall survival , predictive value , prospective study , protein blood level , protein function , survival time , tertiary care center , tumor invasion , aged , blood , cohort analysis , hypoxia , larynx tumor , middle aged , prognosis , very elderly