Effect of Pirfenidone on Vascular Proliferation, Inflammation and Fibrosis in an Abdominal Adhesion Rat Model

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dc.contributor.authorHasdemir P.S.
dc.contributor.authorOzkut M.
dc.contributor.authorGuvenal T.
dc.contributor.authorUner M.A.
dc.contributor.authorCalik E.
dc.contributor.authorKoltan S.O.
dc.contributor.authorKoyuncu F.M.
dc.contributor.authorOzbilgin K.
dc.date.accessioned2024-07-22T08:11:04Z
dc.date.available2024-07-22T08:11:04Z
dc.date.issued2017
dc.description.abstractAim: To study the efficacy of pirfenidone for prevention of postoperative adhesion formation in an adhesion rat model. Materials and Methods: Eighteen female Wistar rats were subjected to right-sided parietal peritoneum and right uterine horn adhesion model. Rats were randomized into three groups: group 1 (control) (closure of midline abdominal incision without any agent administration), group 2 (closure of incision after intraperitoneal administration of pirfenidone), and group 3 (closure of incision and only oral administration of pirfenidone for 14 days). Relaparotomy was performed 14 days after the first surgery. Effect of pirfenidone on adhesion formation was assessed on light microscopy by scoring vascular proliferation, inflammation, fibrosis, and collagen formation in the scarred tissue. Effect of pirfenidone on inflammation was assessed by measurement of transforming growth factor-β and interleukin-17 levels in scarred tissue. Results: The degree of vascular proliferation (1.32 ± 0.39 versus 2.34 ± 0.46, p < 0.001), inflammation (1.60 ± 0.70 versus 2.60 ± 0.52, p < 0.01), and fibrosis (1.50 ± 0.53 versus 2.40 ± 0.52, p < 0.01) were less prominent in group 2 compared to group 1, respectively. Only vascular proliferation was found to be less prominent in group 3 compared to group 1 (1.60 ± 0.42 versus 2.34 ± 0.46, p < 0.01). Intraperitoneal and oral administration of pirfenidone reduced tissue levels of inflammatory markers (TGF-β and IL-17) in parietal and visceral peritoneum compared to control group. Intraperitoneal administration of pirfenidone compared to oral administration was more effective in reducing tissue levels of inflammatory markers. Conclusion: Pirfenidone is an effective agent on the prevention of postoperative vascular proliferation, inflammation and fibrosis in scarred tissue particularly with intraperitoneal administration. Copyright © 2017 Taylor & Francis Group, LLC.
dc.identifier.DOI-ID10.1080/08941939.2016.1215578
dc.identifier.issn08941939
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15477
dc.language.isoEnglish
dc.publisherTaylor and Francis Ltd
dc.subjectAdministration, Oral
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectDisease Models, Animal
dc.subjectFemale
dc.subjectInflammation
dc.subjectInjections, Intraperitoneal
dc.subjectInterleukin-17
dc.subjectNeovascularization, Pathologic
dc.subjectPeritoneum
dc.subjectPostoperative Complications
dc.subjectPyridones
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTissue Adhesions
dc.subjectTransforming Growth Factor beta
dc.subjectTreatment Outcome
dc.subjectUterus
dc.subjectinterleukin 17
dc.subjectpirfenidone
dc.subjecttransforming growth factor beta
dc.subjectIL17 protein, rat
dc.subjectinterleukin 17
dc.subjectnonsteroid antiinflammatory agent
dc.subjectpirfenidone
dc.subjectpyridone derivative
dc.subjecttransforming growth factor beta
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectArticle
dc.subjectcollagen synthesis
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectdrug efficacy
dc.subjectfemale
dc.subjectfibrosis
dc.subjectimmunohistochemistry
dc.subjectinflammation
dc.subjectmicroscopy
dc.subjectnonhuman
dc.subjectperitoneum adhesion
dc.subjectperitoneum cell
dc.subjectphysical disease by etiology and pathogenesis
dc.subjectpriority journal
dc.subjectprophylaxis
dc.subjectuterus horn
dc.subjectvascular proliferation
dc.subjectWistar rat
dc.subjectanimal
dc.subjectdisease model
dc.subjectinflammation
dc.subjectintraperitoneal drug administration
dc.subjectmetabolism
dc.subjectneovascularization (pathology)
dc.subjectoral drug administration
dc.subjectpathology
dc.subjectperitoneum
dc.subjectpostoperative complication
dc.subjectrat
dc.subjecttissue adhesion
dc.subjecttreatment outcome
dc.subjectuterus
dc.titleEffect of Pirfenidone on Vascular Proliferation, Inflammation and Fibrosis in an Abdominal Adhesion Rat Model
dc.typeArticle

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