Pentoxifylline affects cytokine reaction in cardiopulmonary bypass.

Simple item page
dc.contributor.authorIskesen I.
dc.contributor.authorSaribulbul O.
dc.contributor.authorCerrahoglu M.
dc.contributor.authorOnur E.
dc.contributor.authorDestan B.
dc.contributor.authorSirin B.H.
dc.date.accessioned2024-07-22T08:23:34Z
dc.date.available2024-07-22T08:23:34Z
dc.date.issued2006
dc.description.abstractBACKGROUND: Cardiac surgery is associated with an inflammatory response that may cause myocardial dysfunction after cardiopulmonary bypass. We examined the efficacy of pentoxifylline to attenuate the cardiopulmonary bypass-induced inflammatory response during heart operations. METHODS: In a prospective, randomized study, 30 patients undergoing coronary artery bypass graft surgery received either pentoxifylline (group P, n = 15) (continuous infusion of 1.5 mg/kg per hour during operation) or not (group C [control], n = 15). Blood samples for measurements of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-8, and IL-10 were taken from the arterial line in both groups at 5 different time points. RESULTS: TNF-alpha, IL-6, and IL-8 plasma levels increased in both groups after cardiopulmonary bypass, with a higher increase in the control group (P < .05). CONCLUSIONS: Our results indicate that pentoxifylline infusion during cardiac surgery inhibits the proinflammatory cytokine release caused by cardiopulmonary bypass.
dc.identifier.DOI-ID10.1532/hsf98.20061090
dc.identifier.issn15226662
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19578
dc.language.isoEnglish
dc.subjectCardiopulmonary Bypass
dc.subjectCytokines
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMyositis
dc.subjectPentoxifylline
dc.subjectPlatelet Aggregation Inhibitors
dc.subjectTreatment Outcome
dc.subjectantithrombocytic agent
dc.subjectcytokine
dc.subjectpentoxifylline
dc.subjectarticle
dc.subjectblood
dc.subjectcardiopulmonary bypass
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthuman
dc.subjectimmunology
dc.subjectin vitro study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectmyositis
dc.subjectrandomized controlled trial
dc.subjecttreatment outcome
dc.titlePentoxifylline affects cytokine reaction in cardiopulmonary bypass.
dc.typeArticle

Files

Collections

Scopus Koleksiyonu