Serum N-terminal-pro-B-type natriuretic peptide (NT-pro-BNP) levels in hyperthyroidism and hypothyroidism

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dc.contributor.authorÖzmen B.
dc.contributor.authorÖzmen D.
dc.contributor.authorParildar Z.
dc.contributor.authorMutaf I.
dc.contributor.authorBayindir O.
dc.date.accessioned2024-07-22T08:23:08Z
dc.date.available2024-07-22T08:23:08Z
dc.date.issued2006
dc.description.abstractNatriuretic peptides represent a novel diagnostic tool in the assessment of heart failure. N-terminal-pro-B-type natriuretic peptide (NT-proBNP), a member of the natriuretic peptid family, is produced and released from cardiac ventricles. Changes in cardiac functions are observed in thyroid dysfunctions. The aim of this study was to assess the changes in serum NT-proBNP levels and to evaluate impact of thyroid hormones on serum NT-proBNP in patients with hyperthyroidism and hypothyroidism. Serum NT-proBNP levels were measured in 21 patients with hyperthyroidism and in 24 patients with hypothyroidism and compared with 20 healthy control subjects. Patients without cardiac disease were included into the study as well. Serum NT-proBNP levels were measured by electrochemiluminescence immunoassay. Serum NT-proBNP levels were higher in hyperthyroid patients than in hypothyroid patients and in control subjects, with mean values of 239.03 ± 47.33, 45.97 ± 13.48, 55.57 ± 13.01 pg/ml, respectively (p < 0.0001). Serum NT-proBNP and thyroid hormones were correlated in all patients. Moreover, there was a significant positive correlation between serum NT-proBNP and serum free T4 (FT4) levels (r = 0,549, p = 0.012) in hyperthyroidic patients. Multiple regression analyses demonstrated that increasing FT4 was independently associated with a high serum NT-proBNP levels, whereas heart rate was not in hyperthyroid patients. Serum NT-proBNP levels are higher in the hyperthyroid state as compared with the hypothyroid and euthyroid state. Thyroid dysfunction affects serum NT-proBNP levels, possibly influencing the secretion of the peptide. Therefore, thyroid function has to be considered when evaluating high serum NT-proBNP levels in patients without cardiac dysfunction. Copyright © Informa Healthcare USA, Inc.
dc.identifier.DOI-ID10.1080/07435800701670047
dc.identifier.issn15324206
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19385
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAged
dc.subjectCase-Control Studies
dc.subjectFemale
dc.subjectHeart Rate
dc.subjectHumans
dc.subjectHyperthyroidism
dc.subjectHypothyroidism
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNatriuretic Peptide, Brain
dc.subjectPeptide Fragments
dc.subjectThyroid Hormones
dc.subjectThyrotropin
dc.subjectamino terminal pro brain natriuretic peptide
dc.subjectthyroid hormone
dc.subjectbrain natriuretic peptide
dc.subjectpeptide fragment
dc.subjectpro brain natriuretic peptide (1 76)
dc.subjectpro-brain natriuretic peptide (1-76)
dc.subjectthyroid hormone
dc.subjectthyrotropin
dc.subjectunclassified drug
dc.subjectadult
dc.subjectarticle
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectelectroimmunoassay
dc.subjectfemale
dc.subjectheart rate
dc.subjecthuman
dc.subjecthuman tissue
dc.subjecthyperthyroidism
dc.subjecthypothyroidism
dc.subjectmale
dc.subjectpriority journal
dc.subjectprotein blood level
dc.subjectprotein secretion
dc.subjectthyroid function
dc.subjectthyroid hormone blood level
dc.subjectaged
dc.subjectblood
dc.subjectcase control study
dc.subjectcomparative study
dc.subjectmiddle aged
dc.subjectpathophysiology
dc.subjectphysiology
dc.titleSerum N-terminal-pro-B-type natriuretic peptide (NT-pro-BNP) levels in hyperthyroidism and hypothyroidism
dc.typeArticle

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