Cytopathological expression of different types of urothelial carcinoma in situ in urinary bladder washings

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dc.contributor.authorDemir M.A.
dc.contributor.authorRyd W.
dc.contributor.authorAldenborg F.
dc.contributor.authorHolmang S.
dc.date.accessioned2024-07-22T08:24:51Z
dc.date.available2024-07-22T08:24:51Z
dc.date.issued2003
dc.description.abstractOBJECTIVE: To evaluate and compare the cytopathological expression of the five major histological types of carcinoma in situ (CIS) in urinary bladder washings from patients with flat urothelial lesions. MATERIALS AND METHODS: Seventy-five cases of primary and secondary urothelial CIS with no concomitant tumours, and having tissue and cytological samples, were identified. Biopsies were evaluated based on the consensus classification as: large-cell pleomorphic; large-cell non-pleomorphic; small-cell; clinging; and cancerization of the urothelium. In the cytological classification the 'clinging' category was excluded, as its definition depends on the histological appearance. κ statistics were used to evaluate the correlation between histopathology and cytology. RESULTS: More than one subtype of CIS could often be identified in both the histological and cytological specimens. Cytology often showed more subtypes than did histopathology. Statistically, there was only a moderate correlation between histopathology and cytology for recognising different patterns. CONCLUSION: Different patterns of CIS can be identified by cytology; it is important for cytologists to be aware of the cytological spectrum of CIS and not to under-diagnose monomorphic, pagetoid (cancerization) and small-cell forms. Studies on treatments for CIS and of the clinical significance of different subtypes of CIS should include both cytopathology and histopathology.
dc.identifier.DOI-ID10.1111/j.1464-410X.2003.04523.x
dc.identifier.issn14644096
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20159
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAged
dc.subjectBiopsy
dc.subjectCarcinoma in Situ
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectRetrospective Studies
dc.subjectUrinary Bladder
dc.subjectUrinary Bladder Neoplasms
dc.subjectUrothelium
dc.subjectaged
dc.subjectarticle
dc.subjectbiopsy
dc.subjectcancer grading
dc.subjectcarcinoma in situ
dc.subjectcell type
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectcytopathology
dc.subjectdiagnostic accuracy
dc.subjectdiagnostic value
dc.subjectdisease classification
dc.subjectfemale
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectlarge cell carcinoma
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpleomorphic adenoma
dc.subjectpriority journal
dc.subjecturogenital tract tumor
dc.subjecturothelium
dc.titleCytopathological expression of different types of urothelial carcinoma in situ in urinary bladder washings
dc.typeArticle

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