Influence of tamsulosin on the anterior segment parameters and central corneal thickness; [Tamsulosinin ön segment parametreleri ve santral kornea kali{dotless}nli{dotless}ǧi{dotless}na etkisi]

Palamar M.; Emre S.; Turna B.; Yaǧci A.

Influence of tamsulosin on the anterior segment parameters and central corneal thickness; [Tamsulosinin ön segment parametreleri ve santral kornea kali{dotless}nli{dotless}ǧi{dotless}na etkisi]

Date

2014

Authors

Publisher

Turkiye Klinikleri

Abstract

Objective: To investigate the effects of tamsulosin (α-1 adrenergic receptor antagonist) on the main numerical parameters of anterior segment using Pentacam rotating Scheimmpflug camera, and on biomechanical parameters using Reichert Ocular Response Analyser (ORA) in patients with benign prostate hyperplasia. Material and Methods: In addition to full eye examination [best corrected visual acuity, keratometry, intraocular pressure (IOP) measured with Goldmann applanation tonometry], Pentacam [central corneal thickness (CCT), anterior chamber depth, anterior chamber volume, anterior chamber angle, pupil diameter] and ORA (corneal hysteresis, corneal resistance factor, corneal compensated IOP, Goldmann correlated IOP) measurements of 30 eyes of 15 male patients were performed before and one month after tamsulosin therapy. Paired t-test and non-parametric Wilcoxon test were used for comparisons. Results: Mean age in the study group was 61.50±6.10 (range 47-69) years. After tamsulosin treatment, CCT increased and this increment was statistically significant (p=0.002). None of the other parameters that were evaluated showed statistically significant difference after tamsulosin use. Conclusion: Tamsulosin leads to significant increment in CCT. The effects of tamsulosin on CCT should be taken into consideration for proper clinical interpretation in patients using tamsulosin. © 2014 by Türkiye Klinikleri.