The beneficial effects of physical exercise on antioxidant status in asthmatic children

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dc.contributor.authorOnur E.
dc.contributor.authorKabaroĝlu C.
dc.contributor.authorGünay T.
dc.contributor.authorVar A.
dc.contributor.authorYilmaz T.
dc.contributor.authorDündar P.
dc.contributor.authorTikiz C.
dc.contributor.authorGüvenç Y.
dc.contributor.authorYüksel H.
dc.date.accessioned2024-07-22T08:20:24Z
dc.date.available2024-07-22T08:20:24Z
dc.date.issued2011
dc.description.abstractBackground: The pathogenesis of asthma involves both airway inflammation and an oxidant/antioxidant imbalance. It is demonstrated in asthmatic adults that exercise programmes improve lung function, a mechanism yet to be elucidated. The purpose of this study was to investigate the possible beneficial effects of physical exercise on antioxidant status in asthmatic children which may lead to ameliorated lung function. Methods: The study enrolled thirteen control and thirty asthmatic children. The asthmatic group was subdivided into two: the first group receiving only pharmacological treatment (n = 15) and the second receiving pharmacological treatment with exercise programme (n = 15) for 8 weeks. Blood samples were drawn from the subjects before and after treatment periods. As oxidant stress markers blood levels of malondialdehyde (MDA) and total nitric oxide (NO), and as antioxidant status, glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) enzyme activities were assessed. Results: Before any treatment was initiated, MDA and NO levels in the asthmatic group were significantly higher than the controls (3.40 ± 0.96 nmol/ml vs 2.46 ± 0.58 nmol/ml, and 12.53 ± 2.10 vs 9.40 ± 1.39 micromol/L, respectively). Both SOD (p = 0.0001) and GSH-Px (p = 0.023) activities were significantly lower in the asthmatic group. Pharmacological treatment and exercise programme together significantly improved lung performance and decreased the levels of oxidant stress markers, in concordance with a significantly increase in antioxidant enzyme activity measures when compared to the pharmacological treatment. Conclusion: Structured exercise programme in asthmatic children resulted in better lung function, which may be attributed to its effect on antioxidant status. © 2010 SEICAP.
dc.identifier.DOI-ID10.1016/j.aller.2010.04.006
dc.identifier.issn15781267
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18148
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAsthma
dc.subjectBiological Markers
dc.subjectChild
dc.subjectExercise
dc.subjectExercise Therapy
dc.subjectFemale
dc.subjectGlutathione Peroxidase
dc.subjectHumans
dc.subjectMale
dc.subjectMalondialdehyde
dc.subjectNitric Oxide
dc.subjectOxidative Stress
dc.subjectRespiratory Function Tests
dc.subjectSuperoxide Dismutase
dc.subjectglutathione peroxidase
dc.subjectmalonaldehyde
dc.subjectnitric oxide
dc.subjectsuperoxide dismutase
dc.subjectantioxidant activity
dc.subjectarticle
dc.subjectasthma
dc.subjectblood level
dc.subjectblood sampling
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectenzyme activity
dc.subjectexercise
dc.subjecthuman
dc.subjectlung function
dc.subjectoxidative stress
dc.titleThe beneficial effects of physical exercise on antioxidant status in asthmatic children
dc.typeArticle

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