Comparison of blood brain barrier permeability in normal and ovariectomized female rats that demonstrate right or left paw preference

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dc.contributor.authorKutlu N.
dc.contributor.authorMutlu F.
dc.contributor.authorVural K.
dc.contributor.authorCezayirli E.
dc.date.accessioned2024-07-22T08:19:15Z
dc.date.available2024-07-22T08:19:15Z
dc.date.issued2012
dc.description.abstractWe explored the relations among paw preference, cerebral asymmetry and asymmetrical disruption of blood-brain barrier (BBB) permeability in normal and ovariectomized female rats with known paw preference. A high dose of pentylenetetrazol was used to disrupt the BBB and induce acute hypertension. To determine the areas of macroscopic infarct, samples were stained with 2,3,5-triphenyltetrazolium chloride. Histological staining techniques were used to show the areas of infarct microscopically on paraffin sections. Sixty-two percent of the rats demonstrated right paw preference, 24% demonstrated left paw preference and 14% were ambidextrous. Areas of infarct, which indicated destruction of the BBB, were determined microscopically and macroscopically in rats that demonstrated right and left paw preference. We found a relation between permeability of the BBB and paw preference. There may be a relation between paw preference, cerebral asymmetry and asymmetrical destruction of the BBB in rats. Asymmetrical destruction of the BBB in experimental rats was similar to the control group, which had asymmetrically disrupted BBB with respect to paw preference. Like the control rats, asymmetrical areas of infarct consistent with cerebral asymmetry were observed in ovariectomized rats. © 2012 The Biological Stain Commission.
dc.identifier.DOI-ID10.3109/10520295.2012.722228
dc.identifier.issn14737760
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17585
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectBlood-Brain Barrier
dc.subjectCapillary Permeability
dc.subjectCerebral Infarction
dc.subjectConvulsants
dc.subjectFemale
dc.subjectFunctional Laterality
dc.subjectOvariectomy
dc.subjectPentylenetetrazole
dc.subjectRats
dc.subjectStaining and Labeling
dc.subjectconvulsant agent
dc.subjectpentetrazole
dc.subjectanimal
dc.subjectarticle
dc.subjectblood brain barrier
dc.subjectbrain infarction
dc.subjectcapillary permeability
dc.subjectcomparative study
dc.subjectdrug effect
dc.subjectfemale
dc.subjecthemispheric dominance
dc.subjectmetabolism
dc.subjectovariectomy
dc.subjectpathology
dc.subjectphysiology
dc.subjectrat
dc.subjectstaining
dc.titleComparison of blood brain barrier permeability in normal and ovariectomized female rats that demonstrate right or left paw preference
dc.typeArticle

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