Design of chemobrionic and biochemobrionic scaffolds for bone tissue engineering

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dc.contributor.authorAslanbay Guler B.
dc.contributor.authorMorçimen Z.G.
dc.contributor.authorTaşdemir Ş.
dc.contributor.authorDemirel Z.
dc.contributor.authorTurunç E.
dc.contributor.authorŞendemir A.
dc.contributor.authorImamoglu E.
dc.date.accessioned2024-07-22T08:01:07Z
dc.date.available2024-07-22T08:01:07Z
dc.date.issued2024
dc.description.abstractChemobrionic systems have attracted great attention in material science for development of novel biomimetic materials. This study aims to design a new bioactive material by integrating biosilica into chemobrionic structure, which will be called biochemobrionic, and to comparatively investigate the use of both chemobrionic and biochemobrionic materials as bone scaffolds. Biosilica, isolated from Amphora sp. diatom, was integrated into chemobrionic structure, and a comprehensive set of analysis was conducted to evaluate their morphological, chemical, mechanical, thermal, and biodegradation properties. Then, the effects of both scaffolds on cell biocompatibility and osteogenic differentiation capacity were assessed. Cells attached to the scaffolds, spread out, and covered the entire surface, indicating the absence of cytotoxicity. Biochemobrionic scaffold exhibited a higher level of mineralization and bone formation than the chemobrionic structure due to the osteogenic activity of biosilica. These results present a comprehensive and pioneering understanding of the potential of (bio)chemobrionics for bone regeneration. © The Author(s) 2024.
dc.identifier.DOI-ID10.1038/s41598-024-63171-z
dc.identifier.issn20452322
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11338
dc.language.isoEnglish
dc.publisherNature Research
dc.rightsAll Open Access; Gold Open Access
dc.subjectAnimals
dc.subjectBiocompatible Materials
dc.subjectBone and Bones
dc.subjectBone Regeneration
dc.subjectCell Differentiation
dc.subjectDiatoms
dc.subjectHumans
dc.subjectOsteogenesis
dc.subjectTissue Engineering
dc.subjectTissue Scaffolds
dc.subjectbiomaterial
dc.subjectanimal
dc.subjectbone
dc.subjectbone development
dc.subjectbone regeneration
dc.subjectcell differentiation
dc.subjectchemistry
dc.subjectdiatom
dc.subjectdrug effect
dc.subjecthuman
dc.subjectphysiology
dc.subjectprocedures
dc.subjecttissue engineering
dc.subjecttissue scaffold
dc.titleDesign of chemobrionic and biochemobrionic scaffolds for bone tissue engineering
dc.typeArticle

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