Quantitative Analysis of the Activity in Choroidal Neovascularizations after a Single Anti-VEGF injection: OCT Versus OCT Angiography
| dc.contributor.author | Altinisik, M | |
| dc.contributor.author | Kurt, E | |
| dc.contributor.author | Kayikcioglu, O | |
| dc.contributor.author | Yildirim, A | |
| dc.date.accessioned | 2025-04-10T10:26:14Z | |
| dc.date.available | 2025-04-10T10:26:14Z | |
| dc.description.abstract | Purpose: To analyze early quantitative changes in the choroidal neovascularization (CNV) area observed with optical coherence tomography angiography (OCTA) after single anti-vascular endothelial growth factor (anti-VEGF) injection. Materials and Methods: Treatment-naive patients with CNV secondary to neovascular age-related macular degeneration were analyzed immediately before and -4 weeks after anti-VEGF injection. The primary endpoints of the study included changes in CNV total and vascular area. Secondary endpoints were best-corrected visual acuity (BCVA), central macular thickness (cMT), central total macular thickness (cTMT), and subfoveal choroidal thickness (SFCT). Results: A total of 27 patients (69.19 +/- 5.91 years, 21 men/6 women, 14 type 1 NV, 11 type 2 NV, and 2 type 3 NV) were included in the study. There was a significant increase in BCVA and decreases in cMT, cTMT, and SFCT after treatment (p<0.05 for all). CNV total and vascular area changed by -11.55 +/- 44.26% (95% confidence interval [CI]: -29.06 and 5.95; p=0.269) and -21.06 +/- 41.2% (95% CI: -36.45/-5.67; p=0.786), respectively. The cases with decreased cTMT were accompanied by a decrease in CNV area only in 37% of the cases. No significant correlation was detected between cTMT and CNV total and vascular area percentage changes (r = -0.06, p=0.74; r = 0.02, p=0.9, respectively). Conclusions: Changes in CNV total and vascular area seem to have limited sensitivity as a biomarker in terms of activation, as wide variability was observed in CNV area after anti-VEGF injection. | |
| dc.identifier.e-issn | 1744-5205 | |
| dc.identifier.issn | 0882-0538 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/33947 | |
| dc.language.iso | English | |
| dc.title | Quantitative Analysis of the Activity in Choroidal Neovascularizations after a Single Anti-VEGF injection: OCT Versus OCT Angiography | |
| dc.type | Article |