A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis

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dc.contributor.authorKurt Ö.
dc.contributor.authorGirginkardeşler N.
dc.contributor.authorBalcioǧlu I.C.
dc.contributor.authorQ̈zbilgin A.
dc.contributor.authorOk Ü.Z.
dc.date.accessioned2024-07-22T08:22:31Z
dc.date.available2024-07-22T08:22:31Z
dc.date.issued2008
dc.description.abstractRecent reports of the pathogenic potential of Dientamoeba fragilis have underlined the need for an effective treatment against this colon-dwelling protozoan. Metronidazole is a well-known and commonly used anti-protozoal agent, but another 5-nitroimidazole derivative, ornidazole, may be preferable, where available, because of its longer half-life and fewer side-effects. This study compared the efficacies of metronidazole and ornidazole in a group of 112 patients with dientamoebiasis. Patients were randomised into two treatment groups: group.1 (n = 56) received metronidazole for 5 days, 20 mg/kg/day for children and 1.5 g/day for adults, in three oral doses, while group 2 (n = 56) received a single oral dose of ornidazole, 30 mg/kg for children and 2g for adults. Stool samples were examined on the seventh and 14th days after treatment, and clinical symptoms were recorded to evaluate the efficacy of treatment. A statistically significant difference was recorded between the efficacies of ornidazole and metronidazole, both parasitologically (92.9% vs. 69.6%, p 0.001) and clinically (96.4% vs. 76.8%, p 0.001). Patients in the metronidazole group reported more side-effects than patients in the ornidazole group, none of whom required termination of treatment. These results suggest that single-dose ornidazole may be an important alternative agent for the treatment of dientamoebiasis. © 2008 European Society of Clinical Microbiology and Infectious Diseases.
dc.identifier.DOI-ID10.1111/j.1469-0691.2008.02002.x
dc.identifier.issn1198743X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19112
dc.language.isoEnglish
dc.publisherBlackwell Publishing Ltd
dc.rightsAll Open Access; Hybrid Gold Open Access
dc.subjectDientamoeba fragilis
dc.subjectProtozoa
dc.subjectmetronidazole
dc.subjectornidazole
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectanorexia
dc.subjectarticle
dc.subjectchild
dc.subjectclinical trial
dc.subjectcomparative study
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdizziness
dc.subjectdrug efficacy
dc.subjectdrug induced headache
dc.subjectfeces analysis
dc.subjectfemale
dc.subjecthuman
dc.subjectinsomnia
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmetallic taste
dc.subjectnausea
dc.subjectpriority journal
dc.subjectrandomized controlled trial
dc.subjectsarcomastigophora infection
dc.subjectsingle drug dose
dc.subjectstatistical significance
dc.subjectsymptom
dc.subjecttaste disorder
dc.subjectvertigo
dc.subjectvomiting
dc.subjectxerostomia
dc.titleA comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis
dc.typeArticle

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