Intestinal ischemia-reperfusion impairs liver regeneration after partial hepatectomy in rats

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dc.contributor.authorAtici A.E.
dc.contributor.authorKaya Y.
dc.contributor.authorCoskun T.
dc.contributor.authorAral E.
dc.contributor.authorVar A.
dc.date.accessioned2024-07-22T08:25:00Z
dc.date.available2024-07-22T08:25:00Z
dc.date.issued2003
dc.description.abstractBackground/Aims: The deleterious effects of intestinal ischemia-reperfusion on liver are realized, but its effect on the regenerative capacity of the liver has not been studied. Our aim in this study was to determine the effect of intestinal ischemia-reperfusion on liver regeneration. Methodology: Sprague-Dawley rats were randomly divided into six groups; two sham-operated, two hepatectomy, and two hepatectomy with intestinal ischemia-reperfusion groups. To create intestinal ischemia-reperfusion, the superior mesenteric artery and collateral arteries supplying the small intestine were occluded for 20 minutes. Partial hepatectomy was performed during the period of ischemia. Ischemia-reperfusion injury in the mucosal layer of the small intestine was scored in light microscopy. Liver regeneration parameters (proliferating cell nuclear antigen labeling index for hepatocytes and liver regeneration rate), and serum levels of aspartate aminotransferase and alanine aminotransferase were studied on day 1 or 4 after operation. Results: Mucosal injury score was high in the hepatectomy with intestinal ischemia-reperfusion groups. Liver regeneration rate and proliferating cell nuclear antigen labeling index were less in these groups than the hepatectomy groups on day 1 and 4. There were no differences in the serum levels of aspartate aminotransferase and alanine aminotransferase between hepatectomy and hepatectomy with intestinal ischemia-reperfusion groups. The mortality rate was higher in the hepatectomy with intestinal ischemia-reperfusion groups than the other groups. Conclusions: Ischemia and reperfusion of the small intestine impaired liver regeneration with high mortality after partial hepatectomy in the rats.
dc.identifier.issn01726390
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20226
dc.language.isoEnglish
dc.subjectAlanine Transaminase
dc.subjectAnimals
dc.subjectAspartate Aminotransferases
dc.subjectHepatectomy
dc.subjectHepatocytes
dc.subjectIntestinal Mucosa
dc.subjectIntestines
dc.subjectIschemia
dc.subjectLiver Regeneration
dc.subjectMale
dc.subjectProliferating Cell Nuclear Antigen
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectReperfusion Injury
dc.subjectalanine aminotransferase
dc.subjectaspartate aminotransferase
dc.subjectcycline
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcell regeneration
dc.subjectcollateral circulation
dc.subjectcontrolled study
dc.subjectenzyme blood level
dc.subjectinjury scale
dc.subjectintestine blood flow
dc.subjectintestine ischemia
dc.subjectintestine mucosa
dc.subjectintestine perfusion
dc.subjectlabeling index
dc.subjectliver cell
dc.subjectliver regeneration
dc.subjectliver resection
dc.subjectmale
dc.subjectmicroscopic anatomy
dc.subjectmortality
dc.subjectnonhuman
dc.subjectpartial hepatectomy
dc.subjectpostoperative period
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectrandomization
dc.subjectrat
dc.subjectreperfusion injury
dc.subjectscoring system
dc.subjectsmall intestine
dc.subjectsuperior mesenteric artery obstruction
dc.titleIntestinal ischemia-reperfusion impairs liver regeneration after partial hepatectomy in rats
dc.typeArticle

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