Diagnostic and prognostic value of procalcitonin and sTREM-1 levels in sepsis

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dc.contributor.authorBayram H.
dc.contributor.authorTünger Ö.
dc.contributor.authorÇivi M.
dc.contributor.authorYüceyar M.H.
dc.contributor.authorUlman C.
dc.contributor.authorDinç Horasan G.
dc.contributor.authorÇetin Ç.B.
dc.date.accessioned2024-07-22T08:14:10Z
dc.date.available2024-07-22T08:14:10Z
dc.date.issued2015
dc.description.abstractBackground/aim: Sepsis is still a major cause of morbidity and mortality despite the improvements in diagnosis and treatment. The aim of this study was to investigate the values of procalcitonin and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in the diferential diagnosis of patients with sepsis and noninfectious systemic infammatory response syndrome (NI-SIRS) and measure their importance in the prognosis of patients with sepsis. Materials and methods: This prospective study included 41 NI-SIRS and 33 sepsis patients hospitalized in Celal Bayar University Hospital, Manisa, Turkey. Blood samples were taken from NI-SIRS patients on days 0 and 3 and from sepsis patients on days 0, 3, 4, 7, and 14. Clinical status of the patients was determined with the SOFA scoring system. Results: The SOFA scoring system and procalcitonin and sTREM-1 measurements were significant in the differential diagnosis of sepsis and NI-SIRS patients. The SOFA scoring system was considered the most important indicator in determining the prognosis of sepsis patients. Procalcitonin and sTREM-1 levels increased progressively in nonsurvivors and decreased in survivors, but changes were statistically in significant. Conclusion: In the differentiation of sepsis and NI-SIRS, and evaluation of the prognosis of sepsis, combined measurements of procalcitonin and sTREM-1 levels are important. © TÜBİTAK.
dc.identifier.DOI-ID10.3906/sag-1401-103
dc.identifier.issn13000144
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16504
dc.language.isoEnglish
dc.publisherTurkiye Klinikleri Journal of Medical Sciences
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAdult
dc.subjectBiological Markers
dc.subjectCalcitonin
dc.subjectDiagnosis, Differential
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMembrane Glycoproteins
dc.subjectMiddle Aged
dc.subjectPrognosis
dc.subjectProspective Studies
dc.subjectProtein Precursors
dc.subjectReceptors, Immunologic
dc.subjectSepsis
dc.subjectSystemic Inflammatory Response Syndrome
dc.subjectcorticosteroid
dc.subjectprocalcitonin
dc.subjecttriggering receptor expressed on myeloid cells 1
dc.subjectbiological marker
dc.subjectcalcitonin
dc.subjectimmunoglobulin receptor
dc.subjectmembrane protein
dc.subjectprocalcitonin
dc.subjectprotein precursor
dc.subjectTREM1 protein, human
dc.subjectadult
dc.subjectArticle
dc.subjectblood sampling
dc.subjectcontrolled study
dc.subjectdiagnostic test accuracy study
dc.subjectdifferential diagnosis
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectfollow up
dc.subjectGram negative bacterium
dc.subjectGram positive bacterium
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmortality
dc.subjectpredictive value
dc.subjectprognostic assessment
dc.subjectprospective study
dc.subjectsensitivity and specificity
dc.subjectsepsis
dc.subjectSequential Organ Failure Assessment Score
dc.subjectsystemic inflammatory response syndrome
dc.subjectblood
dc.subjectgenetics
dc.subjectmiddle aged
dc.subjectprognosis
dc.subjectsepsis
dc.titleDiagnostic and prognostic value of procalcitonin and sTREM-1 levels in sepsis
dc.typeArticle

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