Boswellia sacra essential oil manages colon cancer stem cells proliferation and apoptosis: a new perspective for cure

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dc.contributor.authorBecer E.
dc.contributor.authorKabadayı H.
dc.contributor.authorBaşer K.H.C.
dc.contributor.authorVatansever H.S.
dc.date.accessioned2024-07-22T08:06:49Z
dc.date.available2024-07-22T08:06:49Z
dc.date.issued2021
dc.description.abstractBoswellia sacra Flueck essential oil is obtained from frankincense obtained from Boswellia sacra trees. The aim of this study was to investigate the in vitro anti-cancer activity of Boswellia sacra (BS) essential oil in CD133+ and CD133- Colo-320 cells. Essential oil was analyzed by GC-MS. CD133+ cells, cancer stem cells, were obtained from the Colo-320 by the MiniMACS system. Cytotoxicity were evaluated with MTT assay. Anti-cancer activity of BS essential oil was investigated by immunocytochemistry. 41 compounds were identified in the essential oil. 1:2 dilution BS essential oil was found to be active against all the cells for 24 h incubation. β-catenin immunoreactivity was significantly decreased in both BS essential oil-treated CD133+ and CD133- Colo-320 cells. Caspase-3 immunoreactivity significantly increased in BS essential oil-treated CD133- Colo-320 cells. We conclude that BS essential oil decreased β-catenin signaling molecules which play a crucial role in cancer cell proliferation. BS essential oil promoted apoptosis in CD133- Colo-320 cells. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.DOI-ID10.1080/10412905.2020.1839586
dc.identifier.issn10412905
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13712
dc.language.isoEnglish
dc.publisherBellwether Publishing, Ltd.
dc.subjectCell death
dc.subjectCell proliferation
dc.subjectCell signaling
dc.subjectDiseases
dc.subjectStem cells
dc.subjectAnticancer activities
dc.subjectCancer stem cells
dc.subjectCatenin signaling
dc.subjectColon cancer
dc.subjectImmunocytochemistry
dc.subjectImmunoreactivities
dc.subjectMTT assays
dc.subjectProliferation and apoptosis
dc.subjectEssential oils
dc.titleBoswellia sacra essential oil manages colon cancer stem cells proliferation and apoptosis: a new perspective for cure
dc.typeArticle

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