Histological investigations on thymus of male rats prenatally exposed to bisphenol A
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2018
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Abstract
Bisphenol A is called as a endocrine-distrupting chemical because of the its steroid-like activity and it used in the construction of plastic containing materials. It is indicated that bisphenol A can pass the human serum, urine, follicular fluid, placenta and umblical cord as a result of the use of substances containing this agent. In this study, we aimed to investigate the effects of bisphenol A on the development of the thymus, a primary lymphoid organ which plays an important role in the specific immunity. The adult pregnant female rats were administered orally with bisphenol A (for 21 days) and postnatal thymus samples were obtained on day 21, 45 and 90 and were performed for histochemical and immunohistochemical staining for CD3, CD4, CD8 and CD79a and TUNEL assay for the apoptotic cells. Evaluation of all groups, CD3, CD4, CD8 and CD79a stainings were decreased in the experimental groups compared with control group. The apoptotic cells were determined in the all groups on day 90 as a result of the thymus involution. It is noted that there was not any histological and morphological damages in the rats prenatally exposed the bisphenol A. The effect of the bisphenol A is unknown in the future, but there is no problem in the adult rats. © 2018 Elsevier Ltd
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Adult , Animals , Benzhydryl Compounds , Humans , Male , Phenols , Rats , Thymus Gland , Rattus , Phenols , Rats , T-cells , 4,4' isopropylidenediphenol , CD3 antigen , CD4 antigen , CD79a antigen , CD8 antigen , 4,4' isopropylidenediphenol , benzhydryl derivative , phenol derivative , Apoptotic cells , Bisphenol A , Bisphenols-A , Endocrine distrupting chemicals , Exposed to , Follicular fluid , Human serum , Male rats , T lymphocytes , Umblical cord , apoptosis , bioassay , endocrine disruptor , histology , immunity , rodent , steroid , adult , animal cell , animal tissue , apoptosis , Article , cell density , comparative study , controlled study , female , histology , human , immunocytochemistry , immunohistochemistry , immunoreactivity , male , nonhuman , percentage of apoptotic cells , prenatal exposure , rat , thymus , TUNEL assay , abnormalities , animal , thymus , Thymus