Effect of propolis on endotoxin-induced uveitis in rabbits

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dc.contributor.authorÖztürk F.
dc.contributor.authorKurt E.
dc.contributor.authorI.nan U.U.
dc.contributor.authorEmiroǧlu L.
dc.contributor.authorI.lker S.S.
dc.contributor.authorSobaci G.
dc.date.accessioned2024-07-22T08:25:36Z
dc.date.available2024-07-22T08:25:36Z
dc.date.issued1999
dc.description.abstractPurpose: To test the anti-inflammatory effect of propolis, a natural bee-produced compound, and compare it with corticosteroids for the treatment of endotoxin-induced uveitis (EIU).Methods: EIU was produced in all rabbits by unilateral intravitreal injection of 2,000 ng Salmonella typhimurium endotoxin. The animals were then divided randomly into three groups as follows: group A received no treatment (control); group B received methylprednisolone (5 mg/0.1 mL) (positive control); and group C received propolis (5 mg/0.16 mL) by anterior sub-Tenon injection at the time of uveitis induction and at 4 and 8 hours after induction. Inflammation was evaluated by clinical manifestations and by measuring the protein concentration and inflammatory cell content of the aqueous humor.Results: The clinical grade, cell count, and protein levels in the aqueous humor were: control group (6.0 ± 0.8, 2,519 ± 470 cells/μL, 32.9 ± 2.4 mg/mL); methylprednisolone group (1.8 ± 0.7, 572 ± 137 cells/μL, 15.2 ± 1.8 mg/mL); and propolis group (2.3 ± 0.5, 503 ± 124 cells/μL, 13.8 ± 1.5 mg/mL). Statistically significant differences were recorded in the treatment groups when compared to the control group (P < .001). The effects of methylprednisolone and propolis on EIU were similar (P > .05).Conclusions: Propolis showed significant anti-inflammatory effects on EIU in rabbits. The mechanism of its action warrants further investigation. Copyright (C) 1999 Japanese Ophthalmological Society.
dc.identifier.DOI-ID10.1016/S0021-5155(99)00027-1
dc.identifier.issn00215155
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20487
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectAqueous Humor
dc.subjectCell Count
dc.subjectEye Proteins
dc.subjectLipopolysaccharides
dc.subjectMethylprednisolone
dc.subjectPropolis
dc.subjectRabbits
dc.subjectSalmonella typhimurium
dc.subjectUveitis, Anterior
dc.subjectcorticosteroid
dc.subjectmethylprednisolone
dc.subjectpropolis
dc.subjectsalmonella endotoxin
dc.subjectanimal model
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectintraocular drug administration
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrabbit
dc.subjectuveitis
dc.titleEffect of propolis on endotoxin-induced uveitis in rabbits
dc.typeArticle

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