The course of spinal tuberculosis (Pott disease): Results of the multinational, multicentre Backbone-2 study

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dc.contributor.authorBatirel A.
dc.contributor.authorErdem H.
dc.contributor.authorSengoz G.
dc.contributor.authorPehlivanoglu F.
dc.contributor.authorRamosaco E.
dc.contributor.authorGülsün S.
dc.contributor.authorTekin R.
dc.contributor.authorMete B.
dc.contributor.authorBalkan I.I.
dc.contributor.authorSevgi D.Y.
dc.contributor.authorGiannitsioti E.
dc.contributor.authorFragou A.
dc.contributor.authorKaya S.
dc.contributor.authorCetin B.
dc.contributor.authorOktenoglu T.
dc.contributor.authorCelik A.D.
dc.contributor.authorKaraca B.
dc.contributor.authorHorasan E.S.
dc.contributor.authorUlug M.
dc.contributor.authorSenbayrak S.
dc.contributor.authorKaya S.
dc.contributor.authorArslanalp E.
dc.contributor.authorHasbun R.
dc.contributor.authorAtes-Guler S.
dc.contributor.authorWillke A.
dc.contributor.authorSenol S.
dc.contributor.authorInan D.
dc.contributor.authorGüclü E.
dc.contributor.authorErtem G.T.
dc.contributor.authorKoc M.M.
dc.contributor.authorTasbakan M.
dc.contributor.authorOcal G.
dc.contributor.authorKocagoz S.
dc.contributor.authorKusoglu H.
dc.contributor.authorGüven T.
dc.contributor.authorBaran A.I.
dc.contributor.authorDede B.
dc.contributor.authorKaradag F.Y.
dc.contributor.authorYilmaz H.
dc.contributor.authorAslan G.
dc.contributor.authorAl-Gallad D.A.
dc.contributor.authorCesur S.
dc.contributor.authorEl-Sokkary R.
dc.contributor.authorSirmatel F.
dc.contributor.authorSavasci U.
dc.contributor.authorKaraahmetoglu G.
dc.contributor.authorVahaboglu H.
dc.date.accessioned2024-07-22T08:12:32Z
dc.date.available2024-07-22T08:12:32Z
dc.date.issued2015
dc.description.abstractWe aimed to describe clinical, laboratory, diagnostic and therapeutic features of spinal tuberculosis (ST), also known as Pott disease. A total of 314 patients with ST from 35 centres in Turkey, Egypt, Albania and Greece were included. Median duration from initial symptoms to the time of diagnosis was 78 days. The most common complications presented before diagnosis were abscesses (69%), neurologic deficits (40%), spinal instability (21%) and spinal deformity (16%). Lumbar (56%), thoracic (49%) and thoracolumbar (13%) vertebrae were the most commonly involved sites of infection. Although 51% of the patients had multiple levels of vertebral involvement, 8% had noncontiguous involvement of multiple vertebral bodies. The causative agent was identified in 41% of cases. Histopathologic examination was performed in 200 patients (64%), and 74% were consistent with tuberculosis. Medical treatment alone was implemented in 103 patients (33%), while 211 patients (67%) underwent diagnostic and/or therapeutic surgical intervention. Ten percent of the patients required more than one surgical intervention. Mortality occurred in 7 patients (2%), and 77 (25%) developed sequelae. The distribution of the posttreatment sequelae were as follows: 11% kyphosis, 6% Gibbus deformity, 5% scoliosis, 5% paraparesis, 5% paraplegia and 4% loss of sensation. Older age, presence of neurologic deficit and spinal deformity were predictors of unfavourable outcome. ST results in significant morbidity as a result of its insidious course and delayed diagnosis because of diagnostic and therapeutic challenges. ST should be considered in the differential diagnosis of patients with vertebral osteomyelitis, especially in tuberculosis-endemic regions. Early establishment of definitive aetiologic diagnosis and appropriate treatment are of paramount importance to prevent development of sequelae. © 2015 European Society of Clinical Microbiology and Infectious Diseases.
dc.identifier.DOI-ID10.1016/j.cmi.2015.07.013
dc.identifier.issn1198743X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16090
dc.language.isoEnglish
dc.publisherElsevier B.V.
dc.rightsAll Open Access; Hybrid Gold Open Access
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAntitubercular Agents
dc.subjectEndemic Diseases
dc.subjectFemale
dc.subjectHumans
dc.subjectInternational Cooperation
dc.subjectMale
dc.subjectMediterranean Region
dc.subjectMiddle Aged
dc.subjectRetrospective Studies
dc.subjectSurgical Procedures, Operative
dc.subjectSurvival Analysis
dc.subjectTreatment Outcome
dc.subjectTuberculosis, Spinal
dc.subjectYoung Adult
dc.subjectethambutol
dc.subjectisoniazid
dc.subjectpyrazinamide
dc.subjectrifampicin
dc.subjectstreptomycin
dc.subjecttuberculostatic agent
dc.subjectabscess
dc.subjectadult
dc.subjectaged
dc.subjectAlbania
dc.subjectantibiotic sensitivity
dc.subjectarthralgia
dc.subjectArticle
dc.subjectbackache
dc.subjectblurred vision
dc.subjectcomputer assisted tomography
dc.subjectdelayed diagnosis
dc.subjectdifferential diagnosis
dc.subjectdisease duration
dc.subjectEgypt
dc.subjectfemale
dc.subjectfever
dc.subjectgibbus deformity
dc.subjectgout
dc.subjectGreece
dc.subjecthearing disorder
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjecthyperuricemia
dc.subjectkyphosis
dc.subjectleukopenia
dc.subjectliver toxicity
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmortality
dc.subjectnausea and vomiting
dc.subjectneurologic disease
dc.subjectnonhuman
dc.subjectnuclear magnetic resonance imaging
dc.subjectoutcome assessment
dc.subjectparaplegia
dc.subjectpriority journal
dc.subjectrash
dc.subjectscintigraphy
dc.subjectscoliosis
dc.subjectsensory dysfunction
dc.subjectspine instability
dc.subjectspine malformation
dc.subjecttuberculous spondylitis
dc.subjectTurkey (republic)
dc.subjectvertigo
dc.subjectadolescent
dc.subjectclinical trial
dc.subjectendemic disease
dc.subjectinternational cooperation
dc.subjectmiddle aged
dc.subjectmulticenter study
dc.subjectpathology
dc.subjectretrospective study
dc.subjectSouthern Europe
dc.subjectsurgery
dc.subjectsurvival analysis
dc.subjecttreatment outcome
dc.subjectTuberculosis, Spinal
dc.subjectvery elderly
dc.subjectyoung adult
dc.titleThe course of spinal tuberculosis (Pott disease): Results of the multinational, multicentre Backbone-2 study
dc.typeArticle

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