Preparation and characterization of PCL-coated porous hydroxyapatite scaffolds in the presence of MWCNTs and graphene for orthopedic applications

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dc.contributor.authorDeliormanlı A.M.
dc.contributor.authorTürk M.
dc.contributor.authorAtmaca H.
dc.date.accessioned2024-07-22T08:08:41Z
dc.date.available2024-07-22T08:08:41Z
dc.date.issued2019
dc.description.abstractMacro-channeled porous hydroxyapatite (HA) scaffolds were fabricated by a polymer foam replication method. Composites were prepared by coating the surface of HA scaffolds with polycaprolactone (PCL) in the presence of graphene nanopowders (in the form of flakes) and multi-walled carbon nanotubes (MWCNTs) at different concentrations. Compression strength of the scaffolds was investigated as a function of additive concentration. Results revealed that the use of PCL coating increased the mechanical strength of HA scaffolds. Besides, addition of graphene or MWCNTs further improved the compression strength of the constructs when they were used at 0.25 wt% and a decrease was observed at higher graphene and MWCNT concentrations. Highest mechanical performance was obtained in composite HA scaffolds involving MWCNTs. In vitro acellular bioactivity experiments revealed that both graphene and MWCNT-incorporated HA scaffolds showed higher bioactivity in simulated body fluid compared to bare scaffolds. However, HA formation ability was more pronounced with MWCNTs compared to graphene nanoflakes where they were possibly acted as an effective nucleation sites to induce the formation of a biomimetic apatite. Additionally, scaffolds prepared in the study were found to be nontoxic to the mouse bone marrow mesenchymal stem cells. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
dc.identifier.DOI-ID10.1007/s10934-018-0644-x
dc.identifier.issn13802224
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14478
dc.language.isoEnglish
dc.publisherSpringer New York LLC
dc.subjectBiomimetics
dc.subjectCell culture
dc.subjectCoatings
dc.subjectCompressive strength
dc.subjectGraphene
dc.subjectHydroxyapatite
dc.subjectPhosphate minerals
dc.subjectPolycaprolactone
dc.subjectScaffolds (biology)
dc.subjectStem cells
dc.subjectTissue engineering
dc.subjectYarn
dc.subjectAdditive concentrations
dc.subjectBiomimetic apatites
dc.subjectCompression strength
dc.subjectMechanical performance
dc.subjectMWCNTs
dc.subjectOrthopedic applications
dc.subjectPorous hydroxyapatite
dc.subjectSimulated body fluids
dc.subjectMultiwalled carbon nanotubes (MWCN)
dc.titlePreparation and characterization of PCL-coated porous hydroxyapatite scaffolds in the presence of MWCNTs and graphene for orthopedic applications
dc.typeArticle

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