The effects of lornoxicam on brain edema and blood brain barrier following diffuse traumatic brain injury in rats; [Lornoksikamin siçanlarda diffüz travmatik beyin hasarinda beyin ödemi ve kan beyin bariyeri üzerine etkileri]

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dc.contributor.authorTopçu I.
dc.contributor.authorGümüşer G.
dc.contributor.authorBayram E.
dc.contributor.authorAras F.
dc.contributor.authorÇetin I.
dc.contributor.authorTemiz C.
dc.contributor.authorÇivi M.
dc.date.accessioned2024-07-22T08:19:10Z
dc.date.available2024-07-22T08:19:10Z
dc.date.issued2013
dc.description.abstractBACKGROUND In this experiment, the effects of lornoxicam on brain edema and the blood brain barrier (BBB) following diffuse traumatic brain injury (TBI) were studied. METHODS Twenty adult male Wistar albino rats were anesthetized, and experimental closed head trauma was induced by the Marmarou method. After head injury, the rats were randomly divided into two groups: Group I was the control group, to which 2 ml saline was administered intraperitoneally, and Group II was the lornoxicam group, to which 2 ml 1.3 mg kg-1 lornoxicam was administered intraperitoneally. Twenty-four hours after head trauma, 99 mTc pentetate (DTPA) was injected at a dose of 37 MBq, and posterior planar images of each rat were obtained using an Infinia gamma camera. After imaging of BBB permeability, brain tissues were dissected from the cranium. The brain water content (BWC) of each sample was calculated using the wet-dry method. RESULTS The lesion/background (L/b) ratio of Group I was 3.76±0.46 and 3.02±0.66 for early (5th min) and late (60th min) imaging, respectively. In Group II, the L/b ratios were 3.52±0.96 and 2.63±0.63 for early and late imaging, respectively (p>0.05). BWC was 79.6±2.5% and 77.5±1.1% for Groups I and II, respectively (p<0.05). CONCLUSION In this rat model of TBI, lornoxicam reduced brain edema but did not affect BBB permeability.
dc.identifier.DOI-ID10.5505/tjtes.2013.32458
dc.identifier.issn1306696X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17561
dc.language.isoEnglish
dc.publisherTurkish Association of Trauma and Emergency Surgery
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectBlood-Brain Barrier
dc.subjectBrain Edema
dc.subjectBrain Injuries
dc.subjectMale
dc.subjectNeuroprotective Agents
dc.subjectPiroxicam
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectlornoxicam
dc.subjectlornoxicam
dc.subjectneuroprotective agent
dc.subjectnonsteroid antiinflammatory agent
dc.subjectpiroxicam
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectblood brain barrier
dc.subjectbrain edema
dc.subjectbrain water
dc.subjectcervical spine dislocation
dc.subjectcontrolled study
dc.subjectimaging
dc.subjectmale
dc.subjectnonhuman
dc.subjectrat
dc.subjecttraumatic brain injury
dc.subjectanalogs and derivatives
dc.subjectanimal
dc.subjectblood brain barrier
dc.subjectbrain edema
dc.subjectBrain Injuries
dc.subjectdrug effects
dc.subjectmetabolism
dc.subjectpathology
dc.subjectrandomization
dc.subjectWistar rat
dc.titleThe effects of lornoxicam on brain edema and blood brain barrier following diffuse traumatic brain injury in rats; [Lornoksikamin siçanlarda diffüz travmatik beyin hasarinda beyin ödemi ve kan beyin bariyeri üzerine etkileri]
dc.typeArticle

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