Complete blood count parameters may have a role in diagnosis of gestational trophoblastic disease

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dc.contributor.authorEskicioglu F.
dc.contributor.authorUlkumen B.A.
dc.contributor.authorCalik E.
dc.date.accessioned2024-07-22T08:14:10Z
dc.date.available2024-07-22T08:14:10Z
dc.date.issued2015
dc.description.abstractObjective: The goal of this study was to investigate whether gestational trophoblastic disease (GTD) and healthy pregnancy differ with respect to complete blood count parameters and these parameters can be used both to explain the pathophysiologic mechanisms and differentiate the two conditions from each other. Methods: The data obtained from 37 women with GTD and 61 healthy pregnancies (control group) regarding platelet (PLT), mean PLT volume (MPV) and PLT distribution width (PDW), and white blood cell (WBC) levels were evaluated. Patients with GTD were further subdivided into two groups composed of 20 partial mole (PM) and 17 complete mole (CM) cases. Results: PDW and WBC were lower in the GTD than the control. There were no differences for PLT and MPV. WBC was lower in PM and both WBC and PDW were lower in CM compared with control. ROC curve analysis revealed an area under curve (AUC) 75.5% for WBC and AUC 69.3% for PDW. A cut-off value was determined 8.19 for WBC with 81.0% sensitivity and 54.1% specificity. While, 15.85 were accepted for PDW, with 87.9% sensitivity and 44.4% specificity. Conclusion: Lower WBC in GTD may suggest that molar pregnancy requires a lower inflammatory reaction facilitating trophoblastic invasion. Lower PDW as an indicator of platelet activation in CM may suggest that CM requires less PLT activation than healthy pregnancy that needs stronger trophoblast invasion for normal placental development. Decreased PDW levels especially < 15.85 and WBC levels < 8.19 may alert clinicians for risk of GTD. © 2015, Professional Medical Publications. All rights reserved.
dc.identifier.DOI-ID10.12669/pjms.313.7229
dc.identifier.issn1682024X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16501
dc.language.isoEnglish
dc.publisherProfessional Medical Publications
dc.rightsAll Open Access; Green Open Access
dc.subjectadult
dc.subjectarea under the curve
dc.subjectArticle
dc.subjectcellular parameters
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdiagnostic test accuracy study
dc.subjectfemale
dc.subjecthuman
dc.subjecthydatidiform mole
dc.subjectleukocyte
dc.subjectplatelet distribution width
dc.subjectsensitivity and specificity
dc.subjectthrombocyte
dc.subjectthrombocyte activation
dc.subjectthrombocyte volume
dc.subjecttrophoblast
dc.subjecttrophoblastic tumor
dc.titleComplete blood count parameters may have a role in diagnosis of gestational trophoblastic disease
dc.typeArticle

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