A multicentre, multinational study of clinical characteristics and prognosis of hepatocellular carcinoma; [Étude multicentrique et multinationale des caractéristiques cliniques et du pronostic du carcinome hépatocellulaire]

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dc.contributor.authorDirican A.
dc.contributor.authorUncu D.
dc.contributor.authorSekacheva M.
dc.contributor.authorArtaç M.
dc.contributor.authorAladashvil A.
dc.contributor.authorErdogan A.
dc.contributor.authorKaplan M.
dc.contributor.authorAlacacıoğlu A.
dc.contributor.authorBoukovinas I.
dc.contributor.authorTurhal N.
dc.date.accessioned2024-07-22T08:03:17Z
dc.date.available2024-07-22T08:03:17Z
dc.date.issued2023
dc.description.abstractBackground: Hepatocellular carcinoma (HCC) is a significant health problem, and the associated mortality rate is increasing. Aim: We aimed to determine the clinical characteristics and prognosis for HCC in member countries of the OncoBridge Study Group. Methods: We recruited 630 patients diagnosed with HCC between 2013 and 2019 from 4 countries (Türkiye, Russia, Georgia, and Greece). Univariate and multivariate analyses were conducted to investigate clinical and laboratory prognostic factors. Receiver operating characteristic (ROC) analysis was used to determine the prognostic value of the neutrophil to lymphocyte ratio (NLR) and alpha-fetoprotein (AFP) value. Results: The 3 most common etiological factors were hepatitis B infection (39.7%), hepatitis C virus infection (17.0%) and non-alcoholic fatty liver disease (9.0%). Median overall survival for the whole group was 25 [95% confidence interval (CI): 15.7–34.2] months. Cut-off values for AFP and NLR were accepted as 200 ng/mL and 3.45, respectively. The area under the ROC curve values for AFP, NLR and NLR+AFP were 0.625 (95% CI: 0.547–0.704), 0.589 (95% CI: 0.512–0.667) and 0.657 (95% CI: 0.583–0.731). From the multivariate analysis, advanced tumour size, lymph node involvement and metastasis (TNM) stage, presence of cirrhosis, high AFP, and high NLR values were associated with poor survival. Conclusion: AFP, NLR, advanced TNM, and presence of cirrhosis may predict prognosis in patients with HCC. Studies involving more countries are needed to corroborate these findings. © Authors 2023; Licensee: World Health Organization.
dc.identifier.DOI-ID10.26719/emhj.23.087
dc.identifier.issn10203397
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12208
dc.language.isoEnglish
dc.publisherWorld Health Organization
dc.rightsAll Open Access; Gold Open Access
dc.subjectalpha-Fetoproteins
dc.subjectCarcinoma, Hepatocellular
dc.subjectHumans
dc.subjectLiver Neoplasms
dc.subjectLymphocytes
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjectROC Curve
dc.subjectacetylsalicylic acid
dc.subjectalpha fetoprotein
dc.subjecthydroxymethylglutaryl coenzyme A reductase inhibitor
dc.subjectsorafenib
dc.subjectsulfonylurea
dc.subjectalpha fetoprotein
dc.subjectablation therapy
dc.subjectadult
dc.subjectalcohol consumption
dc.subjectArticle
dc.subjectcancer prognosis
dc.subjectcancer staging
dc.subjectChild Pugh score
dc.subjectcoding
dc.subjectcontrolled study
dc.subjectdiabetes mellitus
dc.subjectdiagnostic test accuracy study
dc.subjectfemale
dc.subjectGeorgia (republic)
dc.subjectGreece
dc.subjecthepatitis B
dc.subjecthepatitis C
dc.subjecthuman
dc.subjectliver cell carcinoma
dc.subjectliver cirrhosis
dc.subjectlymphocyte count
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmortality rate
dc.subjectmulticenter study
dc.subjectneutrophil count
dc.subjectneutrophil lymphocyte ratio
dc.subjectnonalcoholic fatty liver
dc.subjectoverall survival
dc.subjectpredictive value
dc.subjectprogression free survival
dc.subjectreceiver operating characteristic
dc.subjectretrospective study
dc.subjectRussian Federation
dc.subjectsensitivity and specificity
dc.subjectsmoking
dc.subjecttumor volume
dc.subjectTurkey (republic)
dc.subjectvirus hepatitis
dc.subjectclinical trial
dc.subjectliver cell carcinoma
dc.subjectliver tumor
dc.subjectlymphocyte
dc.subjectpathology
dc.subjectprognosis
dc.titleA multicentre, multinational study of clinical characteristics and prognosis of hepatocellular carcinoma; [Étude multicentrique et multinationale des caractéristiques cliniques et du pronostic du carcinome hépatocellulaire]
dc.typeArticle

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