Multicenter analysis of gestational trophoblastic neoplasia in Turkey

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dc.contributor.authorOzalp S.S.
dc.contributor.authorTelli E.
dc.contributor.authorOge T.
dc.contributor.authorTulunay G.
dc.contributor.authorBoran N.
dc.contributor.authorTuran T.
dc.contributor.authorYenen M.
dc.contributor.authorKurdoglu Z.
dc.contributor.authorOzler A.
dc.contributor.authorYuce K.
dc.contributor.authorUlker V.
dc.contributor.authorArvas M.
dc.contributor.authorDemirkiran F.
dc.contributor.authorBese T.
dc.contributor.authorTokgozoglu N.
dc.contributor.authorOnan A.
dc.contributor.authorSanci M.
dc.contributor.authorGokcu M.
dc.contributor.authorTosun G.
dc.contributor.authorDikmen Y.
dc.contributor.authorOzsaran A.
dc.contributor.authorTerek M.C.
dc.contributor.authorAkman L.
dc.contributor.authorYetimalar H.
dc.contributor.authorKilic D.S.
dc.contributor.authorGungor T.
dc.contributor.authorOzgu E.
dc.contributor.authorYildiz Y.
dc.contributor.authorKokcu A.
dc.contributor.authorKefeli M.
dc.contributor.authorKuruoglu S.
dc.contributor.authorYuksel H.
dc.contributor.authorGuvenal T.
dc.contributor.authorHasdemir P.S.
dc.contributor.authorOzcelik B.
dc.contributor.authorSerin S.
dc.contributor.authorDolanbay M.
dc.contributor.authorArioz D.T.
dc.contributor.authorTuncer N.
dc.contributor.authorBozkaya H.
dc.contributor.authorGuven S.
dc.contributor.authorKulaksiz D.
dc.contributor.authorVarol F.
dc.contributor.authorYanik A.
dc.contributor.authorOgurlu G.
dc.contributor.authorSimsek T.
dc.contributor.authorToptas T.
dc.contributor.authorDogan S.
dc.contributor.authorCamuzoglu H.
dc.contributor.authorApi M.
dc.contributor.authorGuzin K.
dc.contributor.authorCaliskan E.
dc.contributor.authorDoger E.
dc.contributor.authorCakmak B.
dc.contributor.authorIlhan T.T.
dc.date.accessioned2024-07-22T08:17:18Z
dc.date.available2024-07-22T08:17:18Z
dc.date.issued2014
dc.description.abstractBackground: To evaluate the incidence, diagnosis and management of GTN among 28 centers in Turkey. Materials and Methods: A retrospective study was designed to include GTN patients attending 28 centers in the 10-year period between January 2003 and May 2013. Demographical characteristics of the patients, histopathological diagnosis, the International Federation of Gynecology and Obstetrics (FIGO) anatomical and prognostic scores, use of single-agent and multi-agent chemotherapy, surgical interventions and prognosis were evaluated. Results: From 2003-2013, there were 1,173,235 deliveries and 456 GTN cases at the 28 centers. The incidence was calculated to be 0.38 per 1,000 deliveries. According to the evaluated data of 364 patients, the median age at diagnosis was 31 years (range, 15-59 years). A histopathological diagnosis was present for 45.1% of the patients, and invasive mole, choriocarcinoma and PSTTs were diagnosed in 22.3% (n=81), 18.1% (n=66) and 4.7% (n=17) of the patients, respectively. Regarding final prognosis, 352 (96.7%) of the patients had remission, and 7 (1.9%) had persistence, whereas the disease was mortal for 5 (1.4%) of the patients. Conclusions: Because of the differences between countries, it is important to provide national registration systems and special clinics for the accurate diagnosis and treatment of GTN.
dc.identifier.DOI-ID10.7314/APJCP.2014.15.8.3625
dc.identifier.issn15137368
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17025
dc.language.isoEnglish
dc.publisherAsian Pacific Organization for Cancer Prevention
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAntineoplastic Combined Chemotherapy Protocols
dc.subjectChoriocarcinoma
dc.subjectCohort Studies
dc.subjectFemale
dc.subjectGestational Trophoblastic Disease
dc.subjectHumans
dc.subjectHydatidiform Mole, Invasive
dc.subjectHysterectomy
dc.subjectIncidence
dc.subjectMiddle Aged
dc.subjectPregnancy
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjectTrophoblastic Tumor, Placental Site
dc.subjectTurkey
dc.subjectUterine Neoplasms
dc.subjectYoung Adult
dc.subjectantineoplastic agent
dc.subjectadolescent
dc.subjectadult
dc.subjectchoriocarcinoma
dc.subjectclinical trial
dc.subjectcohort analysis
dc.subjectfemale
dc.subjectGestational Trophoblastic Disease
dc.subjecthuman
dc.subjectHydatidiform Mole, Invasive
dc.subjecthysterectomy
dc.subjectincidence
dc.subjectmiddle aged
dc.subjectmulticenter study
dc.subjectpregnancy
dc.subjectprognosis
dc.subjectretrospective study
dc.subjectTrophoblastic Tumor, Placental Site
dc.subjectTurkey
dc.subjectUterine Neoplasms
dc.subjectyoung adult
dc.titleMulticenter analysis of gestational trophoblastic neoplasia in Turkey
dc.typeArticle

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