Salivary inflammatory burden in pre- and postmenopausal women: Associations with body mass index, patient-reported health, serum cytokines, and periodontal parameters

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dc.contributor.authorYakar N.
dc.contributor.authorBostanci N.
dc.contributor.authorÖzdemir G.
dc.contributor.authorAtmaca H.
dc.contributor.authorTüredi A.
dc.contributor.authorŞahin Ç.
dc.contributor.authorKöse T.
dc.contributor.authorEmingil G.
dc.date.accessioned2024-07-22T08:01:36Z
dc.date.available2024-07-22T08:01:36Z
dc.date.issued2024
dc.description.abstractBackground: The decline of estrogen levels during menopause impacts weight, mood, and overall health, both orally and systemically. This study assessed salivary levels of tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), IL-10, and IL-7 in postmenopausal (PMW) and regularly menstruating premenopausal (RMPW) women, while considering serum cytokine levels, body mass index (BMI), periodontal health, and self-reported physical and emotional well-being. Methods: In this study, 75 PMW and 71 RMPW were included. Clinical and periodontal parameters were evaluated, and perceived health was assessed with the Women's Health Questionnaire (WHQ). Cytokine levels in both saliva and serum were quantified by enzyme-linked immunosorbent assay (ELISA). Covariate evaluations of salivary cytokines were conducted using hierarchical linear regression modeling. Results: Cytokines were detectable in saliva from 71 PMW and 67 RMPW. In the initial unadjusted model, IL-7, IL-10, and TNF-α exibited significant differences between RMPW and PMW. However, these differences became non-significant (p > 0.05) in the final model after adjusting for age, which implies a negligible effect of the investigated covariates on salivary cytokine levels when age was considered. Lower levels of IL-6 in PMW, which initially showed no significant difference, became borderline (p = 0.054) in the final model after adjusting for age. Conclusions: After adjusting for multiple factors, no significant difference was found in the salivary levels of the investigated cytokines between RMPW and PMW. Factors such as BMI, perceived health, serum cytokine levels, and periodontal parameters seem to minimally influence these levels in PMW. However, age may be a stronger confounding factor. © 2023 The Authors. Journal of Periodontology published by Wiley Periodicals LLC on behalf of American Academy of Periodontology.
dc.identifier.DOI-ID10.1002/JPER.23-0124
dc.identifier.issn00223492
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11511
dc.language.isoEnglish
dc.publisherJohn Wiley and Sons Inc
dc.rightsAll Open Access; Hybrid Gold Open Access
dc.subjectBody Mass Index
dc.subjectCytokines
dc.subjectFemale
dc.subjectHumans
dc.subjectInterleukin-10
dc.subjectInterleukin-6
dc.subjectInterleukin-7
dc.subjectPatient Reported Outcome Measures
dc.subjectPostmenopause
dc.subjectSaliva
dc.subjectTumor Necrosis Factor-alpha
dc.subjectcytokine
dc.subjectestrogen
dc.subjectinterleukin 10
dc.subjectinterleukin 6
dc.subjectinterleukin 7
dc.subjecttumor necrosis factor
dc.subjectcytokine
dc.subjectinterleukin 10
dc.subjectinterleukin 6
dc.subjectinterleukin 7
dc.subjecttumor necrosis factor
dc.subjectadult
dc.subjectArticle
dc.subjectbleeding on probing
dc.subjectbody mass
dc.subjectclinical trial
dc.subjectcontrolled study
dc.subjectdisease burden
dc.subjectDNA extraction
dc.subjectemotional stability
dc.subjectemotional well-being
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmenstrual cycle
dc.subjectperiodontal disease
dc.subjectperiodontal examination
dc.subjectperiodontal parameters
dc.subjectperiodontal pocket depth
dc.subjectPorphyromonas gingivalis
dc.subjectpostmenopause
dc.subjectpremenopause
dc.subjectquestionnaire
dc.subjectreal time polymerase chain reaction
dc.subjectsalivary inflammatory burden
dc.subjectsleep disorder
dc.subjectsomatoform disorder
dc.subjectvasomotor disorder
dc.subjectwomen's health
dc.subjectbody mass
dc.subjectchemistry
dc.subjectpatient-reported outcome
dc.subjectpostmenopause
dc.subjectsaliva
dc.titleSalivary inflammatory burden in pre- and postmenopausal women: Associations with body mass index, patient-reported health, serum cytokines, and periodontal parameters
dc.typeArticle

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