The role of hypoxia related angiogenesis in uterine smooth muscle tumors

Simple item page
dc.contributor.authorUluer E.T.
dc.contributor.authorInan S.
dc.contributor.authorOzbilgin K.
dc.contributor.authorKaraca F.
dc.contributor.authorDicle N.
dc.contributor.authorSanci M.
dc.date.accessioned2024-07-22T08:13:49Z
dc.date.available2024-07-22T08:13:49Z
dc.date.issued2015
dc.description.abstractMechanisms of hypoxia-related angiogenesis are important for uterine smooth muscle tumors. Factors that are related to angiogenesis during hypoxia include vascular endothelial growth factor (VEGF), hypoxia inducible factor 1α (HIF1α), T-cell intracellular antigen1 (TIA1), eukaryotic translation initiation factor 2α (eIF2α) and thrombospondin 1 (TSP1). We investigated immunoreactivities of VEGF, HIF1α, TIA1, eIF2α and TSP1 using an indirect immunoperoxidase method for formalin fi xed, paraffi n embedded tumors that had been diagnosed as leiomyoma (LMY), cellular leiomyoma (CLM) or leiomyosarcoma (LMS). TSP1 immunoreactivity was scored as moderate, mild or minimal, while VEGF, eIF2α and TIA1 immunoreactivities were scored as mild, moderate and strong in LMY, CLM and LMS samples, respectively. HIF1α immunoreactivity was scored as mild to minimal in LMY, CLM and LMS samples, but showed no statistically signifi cant differences among samples. Although angiogenic factors showed strong immunohistochemical staining intensity in LMS, anti-angiogenic factors showed minimal immunohistochemical intensity. There was no difference in HIF-1α immunoreactivity compared to LMY, CLM and LMS samples. We suggest that HIF1α protein synthesis could be suppressed by eIF2α and TIA1. Furthermore, VEGF could be activated by pathways such as COX2, Ras, NF-κB or c-myc instead of HIF1α. Angiogenesis could trigger and accelerate tumor development; therefore, anti-angiogenic therapy could be useful for treatment of tumors. © 2014 The Biological Stain Commission.
dc.identifier.DOI-ID10.3109/10520295.2014.952339
dc.identifier.issn10520295
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16422
dc.language.isoEnglish
dc.publisherInforma Healthcare
dc.subjectAnoxia
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectLeiomyoma
dc.subjectLeiomyosarcoma
dc.subjectNeovascularization, Pathologic
dc.subjectSmooth Muscle Tumor
dc.subjectUterus
dc.subjectVascular Endothelial Growth Factor A
dc.subjectEukaryota
dc.subjectvasculotropin A
dc.subjectanoxia
dc.subjectfemale
dc.subjecthuman
dc.subjectimmunohistochemistry
dc.subjectleiomyoma
dc.subjectleiomyosarcoma
dc.subjectmetabolism
dc.subjectmuscle tumor
dc.subjectneovascularization (pathology)
dc.subjectpathology
dc.subjectprocedures
dc.subjectuterus
dc.subjectvascularization
dc.titleThe role of hypoxia related angiogenesis in uterine smooth muscle tumors
dc.typeArticle

Files

Collections

Scopus Koleksiyonu