Impact of Secondary Insults in Brain Death After Traumatic Brain Injury

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dc.contributor.authorHeppekcan D.
dc.contributor.authorEkin S.
dc.contributor.authorÇivi M.
dc.contributor.authorAydın Tok D.
dc.date.accessioned2024-07-22T08:08:32Z
dc.date.available2024-07-22T08:08:32Z
dc.date.issued2019
dc.description.abstractIn addition to primary injury in severe head trauma, secondary systemic insults that aggravate the brain injury may result in fatal neurologic outcome. We aim to evaluate the correlation between brain death and secondary systemic insults in 100 patients with severe traumatic brain injury (TBI) admitted to the intensive care unit. We collected data on hypotension and hypoxemia at the time of admission to intensive care unit and data on hypotension, hypoxemia, hypocarbia, hypercarbia, shock, anemia, hyperglycemia, and hyperthermia within the first 24 hours. In addition, we recorded the category of TBI according to computed tomography findings. Twenty-six patients (26%) who developed brain death were significantly younger than survivors. Early hypotension (odds ratio [OR], 10.24; 95% confidence interval [CI], 3.64–28.78; P = .000) and early shock (OR, 8.31; 95% CI, 2.65–26.01; P = .000) were significantly more frequent among brain-death patients. The most featured factor that independently predicted the development of brain death in patients with severe TBI was the existence of hypotension (B–2.74; 95% CI, 0.016–0.252; P = .000). The most common type of injury among brain death patients was a surgically evacuated mass lesion. Although all critical care principles are applied to prevent secondary systemic brain insults, when brain death occurs, the prevention of hypotension will become significant in preserving organs in better condition for procurement. © 2019 Elsevier Inc.
dc.identifier.DOI-ID10.1016/j.transproceed.2019.01.176
dc.identifier.issn00411345
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14440
dc.language.isoEnglish
dc.publisherElsevier USA
dc.subjectAdult
dc.subjectBrain Death
dc.subjectBrain Injuries, Traumatic
dc.subjectFemale
dc.subjectHumans
dc.subjectHypotension
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRetrospective Studies
dc.subjectadult
dc.subjectanemia
dc.subjectArticle
dc.subjectbrain death
dc.subjectconfidence interval
dc.subjectcontrolled study
dc.subjectcorrelational study
dc.subjectdisease association
dc.subjectdisease severity
dc.subjectfemale
dc.subjecthospital admission
dc.subjecthuman
dc.subjecthypercapnia
dc.subjecthyperglycemia
dc.subjecthyperthermia
dc.subjecthypocapnia
dc.subjecthypotension
dc.subjecthypoxemia
dc.subjectintensive care unit
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectobservational study
dc.subjectodds ratio
dc.subjectpriority journal
dc.subjectretrospective study
dc.subjectshock
dc.subjecttraumatic brain injury
dc.subjectbrain death
dc.subjectcomplication
dc.subjecthypotension
dc.subjectmiddle aged
dc.subjectpathology
dc.subjecttraumatic brain injury
dc.titleImpact of Secondary Insults in Brain Death After Traumatic Brain Injury
dc.typeArticle

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