Apoptotic and anti-angiogenic effects of Salvia triloba extract in prostate cancer cell lines

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dc.contributor.authorAtmaca H.
dc.contributor.authorBozkurt E.
dc.date.accessioned2024-07-22T08:12:13Z
dc.date.available2024-07-22T08:12:13Z
dc.date.issued2016
dc.description.abstractPlants, due to their remarkable composition, are considered as natural resources of bioactive compounds with specific biological activities. Salvia genus (Lamiaceae) has been used around the world in complementary medicine since ancient times. We investigated the cytotoxic, apoptotic and anti-angiogenic effects of methanolic Salvia triloba extract (STE) in prostate cancer cells. Cell viability was evaluated by XTT; apoptosis was investigated by DNA fragmentation and caspase 3/7 activity assays. Changes in the angiogenic cytokine levels were investigated by human angiogenesis antibody array. Scratch assay was used to determine the cell motility. STE induced cytotoxicity and apoptosis in a concentration-dependent manner in both cancer cells; however, it was not cytotoxic to normal cells. Cell motility was reduced in PC-3, DU-145 and HUVEC cells by STE treatment. ANG, ENA-78, bFGF, EGF, IGF-1 and VEGF-D levels were significantly decreased by −2.9, −3.7, −1.7, −1.7, −2.0 and −1.8 fold in STE-treated DU-145 cells, however, ANG, IL-8, LEP, RANTES, TIMP-1, TIMP-2 and VEGF levels were significantly decreased by −5.1, −2.0, −2.4, −3.1, −1.5, −2.0 and −2.5 fold in PC-3 cells. These data suggest that STE might be a promising candidate for anti-tumor and anti-angiogenic treatment of prostate cancer. © 2015, International Society of Oncology and BioMarkers (ISOBM).
dc.identifier.DOI-ID10.1007/s13277-015-4208-2
dc.identifier.issn10104283
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15967
dc.language.isoEnglish
dc.publisherSpringer Science and Business Media B.V.
dc.subjectAngiogenesis Inhibitors
dc.subjectApoptosis
dc.subjectBlotting, Western
dc.subjectCell Line
dc.subjectCell Line, Tumor
dc.subjectCell Movement
dc.subjectCell Proliferation
dc.subjectCell Survival
dc.subjectDose-Response Relationship, Drug
dc.subjectDrugs, Chinese Herbal
dc.subjectFluorescent Antibody Technique
dc.subjectHumans
dc.subjectMale
dc.subjectNeovascularization, Pathologic
dc.subjectProstatic Neoplasms
dc.subjectSalvia
dc.subjectTime Factors
dc.subjectVascular Endothelial Growth Factor A
dc.subjectangiogenesis inhibitor
dc.subjectbasic fibroblast growth factor receptor
dc.subjectcaspase 3
dc.subjectcaspase 7
dc.subjectepidermal growth factor
dc.subjectepithelial derived neutrophil activating factor 78
dc.subjectinterleukin 8
dc.subjectplant extract
dc.subjectRANTES
dc.subjectSalvia triloba extract
dc.subjectsomatomedin C
dc.subjecttissue inhibitor of metalloproteinase 1
dc.subjecttissue inhibitor of metalloproteinase 2
dc.subjectunclassified drug
dc.subjectvasculotropin D
dc.subjectangiogenesis inhibitor
dc.subjectherbaceous agent
dc.subjectSalvia extract
dc.subjectvasculotropin A
dc.subjectantiangiogenic activity
dc.subjectapoptosis
dc.subjectArticle
dc.subjectcell motility
dc.subjectcell viability
dc.subjectconcentration response
dc.subjectcontrolled study
dc.subjectDNA fragmentation
dc.subjectdrug effect
dc.subjectenzyme activity
dc.subjectenzyme assay
dc.subjecthuman
dc.subjecthuman cell
dc.subjectmale
dc.subjectpriority journal
dc.subjectprostate cancer cell line
dc.subjectSalvia
dc.subjectSalvia triloba
dc.subjectumbilical vein endothelial cell
dc.subjectapoptosis
dc.subjectcell line
dc.subjectcell motion
dc.subjectcell proliferation
dc.subjectcell survival
dc.subjectchemistry
dc.subjectdose response
dc.subjectdrug effects
dc.subjectfluorescent antibody technique
dc.subjectmetabolism
dc.subjectNeovascularization, Pathologic
dc.subjectpathology
dc.subjectprostate tumor
dc.subjecttime factor
dc.subjecttumor cell line
dc.subjectvascularization
dc.subjectWestern blotting
dc.titleApoptotic and anti-angiogenic effects of Salvia triloba extract in prostate cancer cell lines
dc.typeArticle

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