Frequency of gastroesophageal reflux disease in nonatopic children with asthma-like airway disease

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dc.contributor.authorYüksel H.
dc.contributor.authorYilmaz O.
dc.contributor.authorKirmaz C.
dc.contributor.authorAydogdu S.
dc.contributor.authorKasirga E.
dc.date.accessioned2024-07-22T08:23:24Z
dc.date.available2024-07-22T08:23:24Z
dc.date.issued2006
dc.description.abstractGastroesophageal reflux disease (GERD) is commonly associated with asthma; however, frequency in nonatopic children with asthmatic symptoms is unknown. The aim of this study was to determine the frequency of gastroesophageal reflux (GER) in nonatopic children with asthma-like airway disease that recur despite conventional asthma treatment and to evaluate the clinical response to lansoprazole treatment. Twent-five nonatopic children aged between 1 and 16 years who have asthma-like airway disease and 25 healthy children were included in the study. All cases underwent 24 h pH monitoring with dual sensor catheters. Additionally, acid suppressor treatment was administered to patients diagnosed as having GERD and clinical response was evaluated. Major symptoms encountered in the patient group included wheezing and cough (88%, and 32%, respectively). Reflux episodes were more common in distal esophagus during the prone position (reflux index (RI) of 11.5±10.3 vs. 16.2±9.4 during supine vs. prone). All distal esophageal parameters were significantly higher in the patient group except number of reflux episodes lasting longer than 5 min (RI of 13.3±13.1 vs. 3.9±2.9 in the patient vs. control groups, respectively). There was a significant improvement in symptoms and requirement for medication with treatment (number of systems decreased from 2.3±0.6 to 0.4±0.6, P = 0.00). In conclusion, GERD is significantly more common in nonatopic children with asthma-like airway disease compared to the controls and clinical improvement is significant after acid suppressor treatment. Thus, we suggest that children followed-up with the diagnosis of nonatopic asthma with recurrent exacerbations despite adequate asthma treatment have a high frequency of GER and that lansoprazole treatment may be considered early in management. © 2005 Elsevier Ltd. All rights reserved.
dc.identifier.DOI-ID10.1016/j.rmed.2005.07.006
dc.identifier.issn09546111
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19523
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subject2-Pyridinylmethylsulfinylbenzimidazoles
dc.subjectAnti-Asthmatic Agents
dc.subjectAnti-Ulcer Agents
dc.subjectAsthma
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectChronic Disease
dc.subjectFemale
dc.subjectGastroesophageal Reflux
dc.subjectHumans
dc.subjectHydrogen-Ion Concentration
dc.subjectInfant
dc.subjectMale
dc.subjectOmeprazole
dc.subjectProspective Studies
dc.subjectRecurrence
dc.subjectantacid agent
dc.subjectbronchodilating agent
dc.subjectdexamethasone
dc.subjectfluticasone propionate
dc.subjectlansoprazole
dc.subjectsalbutamol
dc.subjectsteroid
dc.subjectadolescent
dc.subjectarticle
dc.subjectasthma
dc.subjectbody position
dc.subjectchild
dc.subjectclinical article
dc.subjectclinical protocol
dc.subjectcontrolled study
dc.subjectcoughing
dc.subjectdisease association
dc.subjectdisease severity
dc.subjectesophagus
dc.subjectfemale
dc.subjectgastroesophageal reflux
dc.subjecthuman
dc.subjectmale
dc.subjectmonitoring
dc.subjectmorbidity
dc.subjectpH
dc.subjectpriority journal
dc.subjectstatistical analysis
dc.subjectsymptom
dc.subjectwheezing
dc.titleFrequency of gastroesophageal reflux disease in nonatopic children with asthma-like airway disease
dc.typeArticle

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