Allergic rhinitis and its relationship with IL-10, IL-17, TGF-β, IFN-γ, IL 22, and IL-35

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dc.contributor.authorDegirmenci P.B.
dc.contributor.authorAksun S.
dc.contributor.authorAltin Z.
dc.contributor.authorBilgir F.
dc.contributor.authorArslan I.B.
dc.contributor.authorColak H.
dc.contributor.authorUral B.
dc.contributor.authorKahraman D.S.
dc.contributor.authorDiniz G.
dc.contributor.authorOzdemir B.
dc.contributor.authorKırmaz C.
dc.date.accessioned2024-07-22T08:10:09Z
dc.date.available2024-07-22T08:10:09Z
dc.date.issued2018
dc.description.abstractBackground. We aimed in our study to research the role of new cytokines such as IL-35, IL-22, and IL-17 that may form a target for novel treatment approaches. Methods. IL-10, IL-17, TGF-β, IFN-γ, IL-22, and IL-35 serum levels of allergic rhinitis (AR) patients were measured using ELISA method. Allergic sensitization was demonstrated by the skin prick test. Patients only with olive tree sensitivity were evaluated for seasonal AR (SAR). Patients only with mite sensitivity were included in the study for perennial AR (PAR). AR clinic severity was demonstrated by the nasal symptom scores (NSS). Results. In total, 65 AR patients (patient group), having 31 PAR and 34 SAR patients, and 31 healthy individuals (control group) participated in the study. Cytokine levels between the patient group and the control group were compared; IL-17 (p = 0 038), IL-22 (p = 0 001), and TGF-β (p = 0 031) were detected as high in the patient group, and IFN-γ (p < 0 001) was detected as low in the patient group. When correlation analysis was made between age, gender, prick test result, NSS, AR duration, and cytokine levels in the patient group, a negative correlation was detected only between IFN-γ (p = 0 032/r = −0 266) level and NSS. Conclusions. Accompanied by the literature information, these results made us think that T cell subgroups and cytokines have an important role in AR immunopathogenesis. It is thought that future studies to be conducted relating to this subject will form new targets in treatment. Copyright © 2018 P. Bayrak Degirmenci et al.
dc.identifier.DOI-ID10.1155/2018/9131432
dc.identifier.issn02780240
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15100
dc.language.isoEnglish
dc.publisherHindawi Limited
dc.rightsAll Open Access; Gold Open Access
dc.subjectAdult
dc.subjectBiomarkers
dc.subjectFemale
dc.subjectHumans
dc.subjectInterferon-gamma
dc.subjectInterleukins
dc.subjectMale
dc.subjectRhinitis, Allergic
dc.subjectTumor Necrosis Factor-alpha
dc.subjectgamma interferon
dc.subjectinterleukin 10
dc.subjectinterleukin 17
dc.subjectinterleukin 22
dc.subjectinterleukin 35
dc.subjecttransforming growth factor beta
dc.subjectbiological marker
dc.subjectgamma interferon
dc.subjectinterleukin derivative
dc.subjecttumor necrosis factor
dc.subjectadult
dc.subjectage
dc.subjectallergic rhinitis
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectdisease duration
dc.subjectdisease severity
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectgender
dc.subjecthuman
dc.subjectimmunopathogenesis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmite
dc.subjectnonhuman
dc.subjectolive tree
dc.subjectperennial rhinitis
dc.subjectprick test
dc.subjectprospective study
dc.subjectsensitization
dc.subjectsymptomatology
dc.subjectallergic rhinitis
dc.subjectblood
dc.titleAllergic rhinitis and its relationship with IL-10, IL-17, TGF-β, IFN-γ, IL 22, and IL-35
dc.typeArticle

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