Clomiphene citrate does not adversely affect endometrial leukemia inhibitory factor levels

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dc.contributor.authorKuşcu N.K.
dc.contributor.authorKoyuncu F.M.
dc.contributor.authorVar A.
dc.contributor.authorLaçin S.
dc.contributor.authorUyanik B.S.
dc.contributor.authorCeylan E.
dc.date.accessioned2024-07-22T08:25:23Z
dc.date.available2024-07-22T08:25:23Z
dc.date.issued2002
dc.description.abstractThe aim of this study was to compare endometrial leukemia inhibitory factor (LIF) levels in spontaneous and clomiphene citrate (CC)-induced cycles of patients with unexplained infertility. The patients were followed in two consecutive cycles. Endometrial samples were obtained 7 days after ultrasonographic evidence that ovulation has occurred during the spontaneous cycle, then the patients were induced with CC from day 5 to day 9 during the subsequent cycle with 50 mg/day, and ovulation monitoring and endometrial biopsy were performed in the same manner. The samples were obtained using a Pipelle biopsy device without using local anesthesia, and kept in formaldehyde solution until the day of measurement. Then they were homogenized in phosphate buffered distilled water, and LIF levels were detected in the homogenized fluid by ELISA method. Endometrial LIF levels were 470 ± 52 and 501 ± 45 pg/1 gram wet tissue in spontaneous and CC-induced cycles respectively, revealing no significant difference. Ovulation induction with CC did not adversely affect endometrial LIF levels.
dc.identifier.DOI-ID10.1080/gye.16.2.151.154
dc.identifier.issn09513590
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20378
dc.language.isoEnglish
dc.publisherParthenon Publishing Group Ltd
dc.subjectbuffer
dc.subjectclomifene citrate
dc.subjectformaldehyde
dc.subjectleukemia inhibitory factor
dc.subjectlocal anesthetic agent
dc.subjectphosphate
dc.subjectwater
dc.subjectadult
dc.subjectarticle
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectendometrium
dc.subjectendometrium biopsy
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjectfemale infertility
dc.subjectfollow up
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimplantation
dc.subjectmenstrual cycle
dc.subjectovulation
dc.subjectovulation induction
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjecttreatment outcome
dc.titleClomiphene citrate does not adversely affect endometrial leukemia inhibitory factor levels
dc.typeArticle

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