Cryptosporidium spp. During chemotherapy: A cross-sectional study of 94 patients with malignant solid tumor

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dc.contributor.authorKarabey M.
dc.contributor.authorCan H.
dc.contributor.authorÖner T.Ö.
dc.contributor.authorDöşkaya M.
dc.contributor.authorAlak S.E.
dc.contributor.authorDöşkaya A.D.
dc.contributor.authorKarakavuk M.
dc.contributor.authorKöseoğlu A.E.
dc.contributor.authorÜn C.
dc.contributor.authorGürüz A.Y.
dc.contributor.authorAlacacıoğlu A.
dc.contributor.authorPektaş B.
dc.contributor.authorGül A.
dc.contributor.authorKaya S.
dc.contributor.authorGökmen A.A.
dc.date.accessioned2024-07-22T08:05:47Z
dc.date.available2024-07-22T08:05:47Z
dc.date.issued2021
dc.description.abstractBACKGROUND: Cryptosporidium spp. is a protozoan parasite that infects many vertebrate animals, including humans. Since Cryptosporidium spp. can cause chronic life-threatening diarrhea and severe malabsorption in immunocompromised patients, we investigated the prevalence of this parasite among patients undergoing chemotherapy for malignant solid tumors. OBJECTIVE: Investigate the prevalence of Cryptosporidium spp. in stool samples. DESIGN: Cross-sectional. SETTING: Tertiary care. PATIENTS AND METHODS: Stool samples were collected from adult patients with malignant solid tumors receiving chemotherapy and diarrhea. Cryptosporidium spp. prevalence was determined using Ziehl-Neelsen staining, ELISA, and real-time PCR targeting of the COWP gene. MAIN OUTCOME MEASURE: The prevalence of Cryptosporidium spp. in patients undergoing chemotherapy for malignant solid tumors. SAMPLE SIZE: 94 RESULTS: The prevalence was 2.1% (2/94), 5.3% (5/94), and 5.3% (5/94) as detected by Ziehl-Neelsen staining, real-time PCR and ELISA, respectively. The prevalence reached 8.5% (8/94) using all results obtained from the three methods. Among eight positive stool samples, four were positive by at least two different methods (Ziehl-Neelsen staining-ELISA or ELISA-real-time PCR) whereas the remaining four were positive by either ELISA or real-time PCR. CONCLUSION: These findings show the risk of cryptosporidiosis in cancer patients and the necessity to use at least two diagnostic methods during the diagnosis of cryptosporidiosis to reach more accurate and trustworthy results. LIMITATIONS: Further studies with a larger sample size are recommended. Copyright: Copyright © 2021, Annals of Saudi Medicine, Saudi Arabia. This is an open access article under the Creative Commons Attribution-NonCommercialNoDerivatives 4.0 International License (CC BY-NC-ND). The details of which can be accessed at http://creativecommons. org/licenses/bync-nd/4.0/
dc.identifier.DOI-ID10.5144/0256-4947.2021.293
dc.identifier.issn02564947
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13262
dc.language.isoEnglish
dc.publisherKing Faisal Specialist Hospital and Research Centre
dc.rightsAll Open Access; Gold Open Access
dc.subjectAnimals
dc.subjectCross-Sectional Studies
dc.subjectCryptosporidiosis
dc.subjectCryptosporidium
dc.subjectDiarrhea
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectacute myeloid leukemia
dc.subjectadult
dc.subjectArticle
dc.subjectbasal cell carcinoma
dc.subjectbladder cancer
dc.subjectbrain cancer
dc.subjectbreast cancer
dc.subjectcancer chemotherapy
dc.subjectcancer patient
dc.subjectcarcinoma
dc.subjectCD4 lymphocyte count
dc.subjectclinical feature
dc.subjectcolon cancer
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectcryptosporidiosis
dc.subjectCryptosporidium
dc.subjectdiarrhea
dc.subjectdisease duration
dc.subjectenzyme linked immunosorbent assay
dc.subjectesophagus cancer
dc.subjectfeces analysis
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman cell
dc.subjectlarynx cancer
dc.subjectliver cell carcinoma
dc.subjectlung cancer
dc.subjectlymphoma
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectmultiple myeloma
dc.subjectnonhuman
dc.subjectovary cancer
dc.subjectpancreas cancer
dc.subjectpredictive value
dc.subjectprevalence
dc.subjectprostate cancer
dc.subjectreal time polymerase chain reaction
dc.subjectrectum cancer
dc.subjectrenal cell carcinoma
dc.subjectsensitivity and specificity
dc.subjectskin cancer
dc.subjectsolid malignant neoplasm
dc.subjectstaining
dc.subjectstomach cancer
dc.subjecttertiary health care
dc.subjectuterus sarcoma
dc.subjectanimal
dc.subjectcryptosporidiosis
dc.subjectdiarrhea
dc.subjectgenetics
dc.subjectneoplasm
dc.titleCryptosporidium spp. During chemotherapy: A cross-sectional study of 94 patients with malignant solid tumor
dc.typeArticle

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