Scintigraphic evaluation of synovial inflammation in rheumatoid arthritis with 99mtechnetium-labelled human polyclonal immunoglobulin G

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dc.contributor.authorCindaş A.
dc.contributor.authorGökçe-Kutsal Y.
dc.contributor.authorKirth P.O.
dc.contributor.authorCaner B.
dc.date.accessioned2024-07-22T08:25:25Z
dc.date.available2024-07-22T08:25:25Z
dc.date.issued2001
dc.description.abstractThe aim of this study was to investigate whether 99mtechnetium-labelled polyclonal human immunoglobulin G (99mTc-IgG) scintigraphy reflects synovial inflammation in patients with rheumatoid arthritis (RA). We evaluated 29 patients with RA for this reason and found a highly significant correlation between total scintigraphic scores and total tenderness scores (r = 0.781, P < 0.001). A significant correlation was also found between 99mTc-IgG scintigraphic scores and tenderness in all joints other than the shoulders. The 99mTc-IgG scintigraphy had a sensitivity of 69% and specificity of 88% in cases with tenderness and 72% and 81%, respectively, in cases with swelling. Total scintigraphic scores were correlated with serum levels of C-reactive protein (r = 0.401, P < 0.05) but not with erythrocyte sedimentation rate (r = 0.149, P > 0.05). The correlation between disease activity scores and total scintigraphic scores was also found to be significant (r = 0.812, P < 0.001). We suggest that 99mTc-IgG scintigraphy is a reliable and objective method in detecting synovial activity and can be appropriate for observing disease prognosis in clinical trials with RA.
dc.identifier.DOI-ID10.1007/s002960000081
dc.identifier.issn01728172
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20419
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAged
dc.subjectArthritis, Rheumatoid
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunoglobulins
dc.subjectJoints
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectSensitivity and Specificity
dc.subjectSynovitis
dc.subjectTechnetium
dc.subjectC reactive protein
dc.subjectimmunoglobulin G
dc.subjecttechnetium 99m
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectclinical article
dc.subjectcontrast enhancement
dc.subjectdiagnostic imaging
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectrheumatoid arthritis
dc.subjectscintigraphy
dc.subjectscoring system
dc.subjectsensitivity and specificity
dc.subjectsynovitis
dc.titleScintigraphic evaluation of synovial inflammation in rheumatoid arthritis with 99mtechnetium-labelled human polyclonal immunoglobulin G
dc.typeArticle

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