Assessment of the efficacy of absorbable adhesion barriers on dissection in esophagus operations

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dc.contributor.authorYilmaz O.
dc.contributor.authorGenc A.
dc.contributor.authorTaneli F.
dc.contributor.authorDemireli P.
dc.contributor.authorDeliaga H.
dc.contributor.authorTaneli C.
dc.date.accessioned2024-07-22T08:23:00Z
dc.date.available2024-07-22T08:23:00Z
dc.date.issued2007
dc.description.abstractObjective: During childhood, recent repeated operations for esophagus are normally conducted if long gap esophageal atresia exists. During multistaged extrathoracic esophageal elongation procedure, the dissection of the esophagus poses severe problems due to adhesion. However, Gore-Tex membrane may simplify esophagus dissection. The most popular adhesion barriers used today are sodium hyaluronate (Seprafilm®; Genzyme Corp., Cambridge, MA) and oxidized regenerated cellulose (Interceed®; Johnson&Johnson Medical Inc., New Brunswick, NJ). The purpose of this study is to investigate the efficacy of adhesion barriers on esophagus dissection. Methods: In the study, 21 Wistar albino adult male rats were worked on. The rats were randomly divided into three groups, each including seven rats. About 1 cm-segment of the esophagus, located just behind the trachea, was dissected from the surrounding tissues through blunt dissection. Rats in group 1 were wrapped with Seprafilm®, and in group 2 with Interceed®. But the rats in group 3 underwent only esophagus dissection. Three weeks later, during esophagus dissection, adhesion scoring was performed and esophagus was divided into two parts: one for the assessment of hydroxyproline level, and the other for histological examination. Results: When the adhesion scores of the three groups were compared, there was not a significant difference between the groups (p = 0.75). In terms of tissue hydroxyproline levels, mean scores of hydroxyproline revealed no significant difference between the three groups (p = 0.19). When the histopathological results were examined, esophagus looked normal and no connective tissues were seen around esophagus. Conclusion: Seprafilm® and Interceed® had no effect on esophagus dissection. Although Seprafilm® had the best mean score, this was statistically insignificant. Gore-Tex might play a better role than Interceed® in preventing adhesion formation; however, it is still not certain whether adhesion barrier should be used in such organs as esophagus having no serosa.
dc.identifier.DOI-ID10.1016/j.ijporl.2006.11.010
dc.identifier.issn01655876
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19340
dc.language.isoEnglish
dc.subjectAbsorbable Implants
dc.subjectAdhesions
dc.subjectAnimals
dc.subjectEsophageal Atresia
dc.subjectHyaluronic Acid
dc.subjectMale
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRats, Wistar
dc.subjecthyaluronic acid
dc.subjectoxidized regenerated cellulose
dc.subjectpolitef
dc.subjectadhesion
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdisease model
dc.subjectdissection
dc.subjectesophagus atresia
dc.subjectesophagus surgery
dc.subjecthistology
dc.subjecthistopathology
dc.subjectintermethod comparison
dc.subjectmale
dc.subjectnonhuman
dc.subjectoutcome assessment
dc.subjectpostoperative complication
dc.subjectpriority journal
dc.subjectrat
dc.subjectscoring system
dc.subjectWistar rat
dc.titleAssessment of the efficacy of absorbable adhesion barriers on dissection in esophagus operations
dc.typeArticle

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