Effects of mirabegron on JJ stent-related symptoms: A multicentric study
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Date
2021
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Abstract
Aims of the study: To investigate the effect of mirabegron 50 mg/daily for JJ stent-related symptoms after ureteroscopic stone surgery. Methods: Medical records of 145 patients who were given a single daily oral dose of 50 mg of mirabegron for relieving stent-related symptoms were retrospectively analysed. Demographic and clinical data and stone parameters were recorded. All participants completed the Turkish version of the Ureter Symptom Score Questionnaire (USSQ-T) on the postoperative 7th day, and again after at least 3 weeks, before JJ stent removal. The severity of stent-related symptoms was statistically compared before and after the mirabegron treatment. Results: The mean urinary symptoms score decreased significantly from 30.87 ± 9.43 to 22.61 ± 6.78 (P <.0001), mean body pain score decreased significantly from 21.82 ± 11.22 to 14.03 ± 7.52 (P <.0001), mean work performance score decreased from 10.50 ± 8.61 to 7.02 ± 6.51 (P <.0001) and mean general health score decreased significantly from 15.43 ± 6.50 to 11.12 ± 3.70 (P <.0001). The mean sexual matters score significantly decreased from 3.88 ± 3.40 to 2.48 ± 2.03 (P <.0001), the additional problem score decreased from 9.31 ± 4.61 to 6.51 ± 2.83 (P <.0001) and the overall quality of life (QoL) score decreased from 5.18 ± 1.94 to 4.23 ± 1.71 after mirabegron use (P <.0001). Conclusion: Daily use of 50 g of mirabegron significantly improved stent-related symptoms, sexual matters and quality of life. © 2020 John Wiley & Sons Ltd
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Acetanilides , Humans , Quality of Life , Retrospective Studies , Stents , Surveys and Questionnaires , Thiazoles , Ureter , mirabegron , acetanilide derivative , mirabegron , thiazole derivative , adult , Article , demography , device removal , drug effect , drug use , female , human , job performance , major clinical study , male , middle aged , postoperative period , priority journal , quality of life , questionnaire , retrospective study , scoring system , single drug dose , ureter stone , ureter surgery , ureteroscopy , adverse device effect , clinical trial , multicenter study , quality of life , stent , ureter