Effects of chronic amiodarone treatment on rat testis

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dc.contributor.authorÖzkaya A.K.
dc.contributor.authorDilber E.
dc.contributor.authorGürgen S.G.
dc.contributor.authorKutlu Ö.
dc.contributor.authorCansu A.
dc.contributor.authorGedik Y.
dc.date.accessioned2024-07-22T08:12:05Z
dc.date.available2024-07-22T08:12:05Z
dc.date.issued2016
dc.description.abstractAmiodarone is a potent agent used to treat tachyarrhythmias, which are especially refractory to other medications, in both adults and children. Although widely used as an antiarrhythmic drug, amiodarone causes many serious adverse effects that limit its use. This study investigated the possible morphological and apoptotic effects of amiodarone on rat testes. Amiodarone was administered to male Sprague-Dawley rats at doses of 20 or 200 mg/kg/day for 14 days. A histopathological examination of testicular tissue revealed the presence of inflammatory cells in the seminiferous tubule lumen together with swelling and vacuolization in the cytoplasm of some spermatogonia; these effects occured in a dose-dependent manner. Immunohistochemical staining showed evidence of apoptosis, including caspase-3, caspase-9, Bax and increased DNA fragmentation was detected via a terminal deoxynucleotidyl transferase dUTP nick-end labeling assay. In conclusion, the results show that chronic amiodarone treatment causes dose-dependent degenerative and apoptotic effects on rat testes. © 2016 Elsevier GmbH.
dc.identifier.DOI-ID10.1016/j.acthis.2016.02.003
dc.identifier.issn00651281
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15908
dc.language.isoEnglish
dc.publisherElsevier GmbH
dc.subjectAmiodarone
dc.subjectAnimals
dc.subjectAnti-Arrhythmia Agents
dc.subjectApoptosis
dc.subjectDNA Fragmentation
dc.subjectMale
dc.subjectRats, Sprague-Dawley
dc.subjectSpermatogonia
dc.subjectTestis
dc.subjectamiodarone
dc.subjectcaspase 3
dc.subjectcaspase 9
dc.subjectprotein Bax
dc.subjectamiodarone
dc.subjectantiarrhythmic agent
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectapoptosis
dc.subjectArticle
dc.subjectcell vacuole
dc.subjectcontrolled study
dc.subjectcytoplasm
dc.subjectDNA fragmentation
dc.subjectdrug exposure
dc.subjecthistopathology
dc.subjectinflammatory cell
dc.subjectmale
dc.subjectnonhuman
dc.subjectrat
dc.subjectreproductive toxicity
dc.subjectscrotal swelling
dc.subjectseminiferous tubule
dc.subjectspermatogonium
dc.subjecttestis
dc.subjecttreatment duration
dc.subjectanimal
dc.subjectdrug effects
dc.subjectpathology
dc.subjectSprague Dawley rat
dc.subjecttestis
dc.titleEffects of chronic amiodarone treatment on rat testis
dc.typeArticle

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