Determination of apoptosis and cell cycle modulators (p16, p21, p27, p53, BCL-2, Bax, BCL-XL, and cyclin D1) in thyroid follicular carcinoma, follicular adenoma, and adenomatous nodules via a tissue microarray method

Simple item page
dc.contributor.authorTemiz P.
dc.contributor.authorAkkaş G.
dc.contributor.authorNeşe N.
dc.contributor.authorUğur Duman F.
dc.contributor.authorKarakaş C.
dc.contributor.authorErhan Y.
dc.date.accessioned2024-07-22T08:13:22Z
dc.date.available2024-07-22T08:13:22Z
dc.date.issued2015
dc.description.abstractBackground/aim: To identify the role of gene products associated with apoptosis and cell cycle in the pathogenesis of thyroid follicular neoplasm. Materials and methods: Thirty follicular adenomas (FAs), 16 follicular carcinomas (FCs), and 20 adenomatous nodules (ANs) were investigated with immunohistochemical staining of p16, p21, p27, p53, Bcl-2, Bax, Bcl-xL, and cyclin D1 via a tissue microarray method. Results: Bcl-2 showed a significant difference between the benign groups (AN and FA) and the malignant group (FC). Bax was significantly higher in the FC group. p53 was lowest in the AN group and highest in the FC group with significant differences between the groups. p16 was significantly higher in the FC group than in the other groups. There was a significant difference between the AN group and neoplastic lesions in terms of p21 staining. The number of cases with positive p27 was lower in the AN group than the neoplastic groups. There was no significant difference in terms of Bcl-xL and cyclin D1. Conclusion: Cell cycle modulators, led by the Bcl-2 family, played an important role in the pathogenesis of thyroid follicular neoplasm, and p53, p16, and p21 in particular played a role in the carcinogenesis of FC. © TÜBİTAK.
dc.identifier.DOI-ID10.3906/sag-1406-48
dc.identifier.issn13000144
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16324
dc.language.isoEnglish
dc.publisherTurkiye Klinikleri
dc.rightsAll Open Access; Hybrid Gold Open Access
dc.subjectAdenocarcinoma, Follicular
dc.subjectAdenoma
dc.subjectAdult
dc.subjectApoptosis
dc.subjectbcl-2-Associated X Protein
dc.subjectCell Cycle Checkpoints
dc.subjectCell Cycle Proteins
dc.subjectCyclin D1
dc.subjectFemale
dc.subjectHumans
dc.subjectHyperplasia
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectThyroid Neoplasms
dc.subjectThyroid Nodule
dc.subjectTissue Array Analysis
dc.subjectcell cycle protein
dc.subjectcyclin D1
dc.subjectprotein Bax
dc.subjectprotein bcl 2
dc.subjectprotein bcl xl
dc.subjectprotein p16
dc.subjectprotein p21
dc.subjectprotein p27
dc.subjectprotein p53
dc.subjectcell cycle protein
dc.subjectcyclin D1
dc.subjectprotein Bax
dc.subjectadenomatous polyp
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectapoptosis
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectfollicular carcinoma
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectthyroid follicular carcinoma
dc.subjectthyroidectomy
dc.subjecttissue microarray
dc.subjectadenocarcinoma
dc.subjectadenoma
dc.subjectcell cycle checkpoint
dc.subjecthyperplasia
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectpathology
dc.subjectthyroid nodule
dc.subjectthyroid tumor
dc.subjecttissue microarray
dc.titleDetermination of apoptosis and cell cycle modulators (p16, p21, p27, p53, BCL-2, Bax, BCL-XL, and cyclin D1) in thyroid follicular carcinoma, follicular adenoma, and adenomatous nodules via a tissue microarray method
dc.typeArticle

Files

Collections

Scopus Koleksiyonu