Effects of selenium on endothelial dysfunction and metabolic profile in low dose streptozotocin induced diabetic rats fed a high fat diet

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dc.contributor.authorOzturk Z.
dc.contributor.authorGurpinar T.
dc.contributor.authorVural K.
dc.contributor.authorBoyacioglu S.
dc.contributor.authorKorkmaz M.
dc.contributor.authorVar A.
dc.date.accessioned2024-07-22T08:12:51Z
dc.date.available2024-07-22T08:12:51Z
dc.date.issued2015
dc.description.abstractEndothelial dysfunction develops as a result of oxidative stress and is responsible for diabetic vascular complications. We investigated the effects of selenium on endothelial dysfunction and oxidative stress in type 2 diabetic rats. Male Wistar rats were divided into five groups: controls, untreated diabetics, and diabetics treated with 180, 300, 500 mcg/kg selenium each day. Diabetes was induced by a single intraperitoneal injection of low dose streptozotocin to rats fed a high fat diet. Endothelium-dependent and-independent relaxations were measured in the thoracic aorta. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and endothelial nitric oxide synthase (eNOS) mRNA expressions were analyzed using real-time polymerase chain reaction (RT-PCR). Fasting blood glucose, lipid profile, lipid oxidation, insulin and nitric oxide were measured in blood samples. Malondialdehyde, superoxide dismutase, catalase and glutathione peroxidase levels were measured in liver samples. RT-PCR showed that selenium reversed increased NADPH oxidase expression and decreased eNOS expression to control levels. Selenium also improved the impairment of endothelium-dependent vasorelaxation in the diabetic aorta. Selenium treatment significantly decreased blood glucose, cholesterol and triglyceride levels, and enhanced the antioxidant status in diabetic rats. Our findings suggest that selenium restores a normal metabolic profile and ameliorates vascular responses and endothelial dysfunction in diabetes by regulating antioxidant enzyme and nitric oxide release. © 2015 The Biological Stain Commission.
dc.identifier.DOI-ID10.3109/10520295.2015.1042050
dc.identifier.issn10520295
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16192
dc.language.isoEnglish
dc.publisherTaylor and Francis Ltd.
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectDiabetes Mellitus, Experimental
dc.subjectDiet, High-Fat
dc.subjectEndothelium
dc.subjectMale
dc.subjectNitric Oxide Synthase Type III
dc.subjectRats, Wistar
dc.subjectSelenium
dc.subjectStreptozocin
dc.subjectantioxidant
dc.subjectendothelial nitric oxide synthase
dc.subjectselenium
dc.subjectstreptozocin
dc.subjectanimal
dc.subjectchemically induced
dc.subjectdrug effects
dc.subjectendothelium
dc.subjectexperimental diabetes mellitus
dc.subjectlipid diet
dc.subjectmale
dc.subjectmetabolism
dc.subjectWistar rat
dc.titleEffects of selenium on endothelial dysfunction and metabolic profile in low dose streptozotocin induced diabetic rats fed a high fat diet
dc.typeArticle

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