Efficacy of leukotriene antagonists as concomitant stherapy in allergic rhinitis

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dc.contributor.authorCingi C.
dc.contributor.authorGunhan K.
dc.contributor.authorGage-White L.
dc.contributor.authorUnlu H.
dc.date.accessioned2024-07-22T08:20:47Z
dc.date.available2024-07-22T08:20:47Z
dc.date.issued2010
dc.description.abstractObjectives/Hypothesis: The symptoms of allergic rhinitis result from an immunoglobulin E-dependent mast cell activation cascade, marked by the release of inflammatory mediators, including histamine. Patients with perennial allergic rhinitis also have elevated levels of cysteinyl leukotrienes (CysLTs) in nasal lavage fluid. Histamine and CysLTs produce different responses in the pathogenesis of allergic rhinitis, and this study tested the hypothesis that the effects of combined antihistamine and leukotriene antagonist therapy would be more effective than antihistamine alone. Study Design: Multicentered, prospective, randomized, placebo-controlled, parallel-group. Methods: Three groups totaling 275 patients using: 1) fexofenadine alone, 2) fexofenadine with montelukast, or 3) fexofenadine with placebo, participated in a 21-day trial conducted during the spring pollen season. Objective analysis included pre- and poststudy physical examination findings and nasal resistance measurements. Subjective data gathered included a daily patient diary and pre- and poststudy patient satisfaction measurements. Results: The group using both fexofenadine and montelukast showed significantly better control of nasal congestion both subjectively, using patient diary and visual analog scale evaluations, and objectively, using rhinomanometry and physical examination, compared to groups using antihistamine alone or with placebo. Conclusions: Our data provided both objective and subjective evidence that leukotriene receptor antagonist- antihistamine combination therapy is more effective than antihistamine alone in the control of allergic rhinitis symptoms. © 2010 The American Laryngological, Rhinological and Otological Society, Inc.
dc.identifier.DOI-ID10.1002/lary.20941
dc.identifier.issn0023852X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18328
dc.language.isoEnglish
dc.subjectAcetates
dc.subjectAdult
dc.subjectAirway Resistance
dc.subjectAnti-Allergic Agents
dc.subjectCase-Control Studies
dc.subjectDrug Therapy, Combination
dc.subjectFemale
dc.subjectHumans
dc.subjectLeukotriene Antagonists
dc.subjectMale
dc.subjectPain Measurement
dc.subjectPatient Satisfaction
dc.subjectQuinolines
dc.subjectRhinitis, Allergic, Perennial
dc.subjectRhinomanometry
dc.subjectTerfenadine
dc.subjectTreatment Outcome
dc.subjectfexofenadine
dc.subjectmontelukast
dc.subjectplacebo
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectallergic rhinitis
dc.subjectarticle
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectdrug efficacy
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmulticenter study
dc.subjectnasal lavage
dc.subjectpatient satisfaction
dc.subjectphysical examination
dc.subjectpriority journal
dc.subjectrandomized controlled trial
dc.subjectrhinomanometry
dc.titleEfficacy of leukotriene antagonists as concomitant stherapy in allergic rhinitis
dc.typeArticle

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