Effects of porcine pancreatic enzymes on the pancreas of hamsters. Part 2: Carcinogenesis studies

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dc.contributor.authorNozawa F.
dc.contributor.authorYalniz M.
dc.contributor.authorSaruc M.
dc.contributor.authorStandop J.
dc.contributor.authorEgami H.
dc.contributor.authorPour P.M.
dc.date.accessioned2024-07-22T08:19:18Z
dc.date.available2024-07-22T08:19:18Z
dc.date.issued2012
dc.description.abstractContext Our previous study suggested that porcine pancreatic extract in hamsters with peripheral insulin resistance, normalizes insulin output, islet size and pancreatic DNA synthetic rate. It also inhibited the growth of human pancreatic cancer cells in nude mice. Objective To examine the potential value of the porcine pancreatic extract in controlling pancreatic carcinogenesis in this model, the present experiment was performed. Design Hamsters were fed a high fat diet and four weeks later when insulin resistance emerges, they were divided into two groups. One group received 1 g/kg BW of porcine pancreatic extract in drinking water and the other group received tap water. One week later, when insulin output normalizes in porcine pancreatic extract-treated hamsters, a single subcutaneous injection of N-nitrosobis-(2-oxopropyl) amine (BOP) at a dose of 40 mg/kg BW was given to all hamsters. The experiment was terminated at 43 weeks after the porcine pancreatic extract treatment. The number and size of pancreatic tumors, blood glucose, insulin, amylase and lipase levels, the average size of islets and the number of insulin cells/islets were determined. Results The incidence of pancreatic cancer was significantly lower in the porcine pancreatic extract group (P=0.043), as well as the plasma insulin level and the size of the islets in the porcine pancreatic extract group were significantly lower (P<0.001) than in the control group. No significantly differences were found in the glucose level between the groups. Conclusion These results show that porcine pancreatic extract has a potential to inhibit pancreatic cancer growth.
dc.identifier.issn15908577
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17622
dc.language.isoEnglish
dc.subjectAmylases
dc.subjectAnalysis of Variance
dc.subjectAnimals
dc.subjectBlood Glucose
dc.subjectBody Weight
dc.subjectCell Transformation, Neoplastic
dc.subjectCricetinae
dc.subjectDietary Fats
dc.subjectEating
dc.subjectFemale
dc.subjectInsulin
dc.subjectInsulin Resistance
dc.subjectIslets of Langerhans
dc.subjectLipase
dc.subjectMale
dc.subjectMesocricetus
dc.subjectOrgan Size
dc.subjectPancreas
dc.subjectPancreatic Neoplasms
dc.subjectPancreatin
dc.subjectSwine
dc.subjectTime Factors
dc.subjectamylase
dc.subjectbis(2 oxopropyl)nitrosamine
dc.subjectdrinking water
dc.subjectfeces lipid
dc.subjectglucose
dc.subjectinsulin
dc.subjectpancreas enzyme
dc.subjecttriacylglycerol lipase
dc.subjectamylase blood level
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectbody weight
dc.subjectcarcinogenesis
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectfemale
dc.subjectfluid intake
dc.subjectfood intake
dc.subjectglucose blood level
dc.subjectinsulin blood level
dc.subjectinsulin resistance
dc.subjectmale
dc.subjectnonhuman
dc.subjectpancreas cancer
dc.subjectpancreas islet alpha cell
dc.subjectpancreas islet beta cell
dc.subjectSyrian hamster
dc.subjecttriacylglycerol lipase blood level
dc.subjecttumor volume
dc.subjecturinalysis
dc.titleEffects of porcine pancreatic enzymes on the pancreas of hamsters. Part 2: Carcinogenesis studies
dc.typeArticle

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