The Prognostic Impact of Tumor Microenvironment and Checkpoint Blockade-Associated Molecules (PD-1, PD-L1, CD163 and CD14) in Nodal Diffuse Large B-cell Lymphoma, NOS
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Date
2024
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Abstract
It is aimed to determine expression of programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), CD163 and CD14 in diffuse large B-cell lymphomas (DLBCL), and whether these markers may predict prognosis in DLBCL cases. A total of 52 nodal DLBCL, NOS cases with no known extranodal involvement at the time of diagnosis were evaluated. PD-1, PD-L1, CD163, and CD14 were studied by immunohistochemistry. The relationships between the results and clinical and laboratory prognostic markers were investigated. It was observed that patients with PD-1 expression < 5 positive cells/HPF had worse overall survival. No significant relationship was found between survival and PD-L1, CD163 and CD14 expressions. In addition, cases that are > 60 years of age, that have Eastern Cooperative Oncology Group (ECOG) performance score ≥ 2, stage IV disease, high International Prognostic Index score score (≥ 3), elevation of LDH, low albumin level, low hemoglobin level, low peripheral blood lymphocyte count, high peripheral blood neutrophil/lymphocyte ratio, high peripheral blood platelet/lymphocyte ratio were found to have worse overall survival. It was concluded that in patients with low number of PD-1 positive tumor-infiltrating lymphocytes have low survival rates and therefore PD-1 expression may be useful in indicating prognosis. © The Author(s), under exclusive licence to Indian Society of Hematology and Blood Transfusion 2023.
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albumin , CD14 antigen , CD163 antigen , cyclophosphamide , doxorubicin , hemoglobin , lactate dehydrogenase , prednisone , programmed death 1 ligand 1 , programmed death 1 receptor , rituximab , vincristine , adult , aged , albumin blood level , antigen expression , Article , cancer prognosis , cancer recurrence , cancer staging , carcinogenesis , clinical feature , controlled study , correlation analysis , diffuse large B cell lymphoma , disease association , ECOG Performance Status , female , hemoglobin blood level , human , International Prognostic Index , lactate dehydrogenase blood level , lymphocyte count , lymphocyte monocyte ratio , lymphocytic infiltration , major clinical study , male , mean survival time , neutrophil count , neutrophil lymphocyte ratio , overall survival , platelet count , platelet lymphocyte ratio , protein expression , tumor associated leukocyte , tumor microenvironment