Gingival crevicular fluid galectin-3 and interleukin-1 beta levels in stage 3 periodontitis with grade B and C

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dc.contributor.authorAfacan B.
dc.contributor.authorIlhan H.A.
dc.contributor.authorKöse T.
dc.contributor.authorEmingil G.
dc.date.accessioned2024-07-22T08:02:39Z
dc.date.available2024-07-22T08:02:39Z
dc.date.issued2023
dc.description.abstractObjectives: This study aims to evaluate GCF Galectin-3 and Interleukin-1 beta (IL-β) levels in different grades (B and C) of stage 3 periodontitis, concurrently, and also to investigate their discriminative efficiencies in periodontal diseases. Materials and methods: A total of 80 systemically healthy and non-smoker individuals, 20 stage 3 grade C (S3GC) periodontitis 20 stage 3 grade B (S3GB) periodontitis, 20 gingivitis, and 20 periodontally healthy were enrolled. Clinical periodontal parameters were recorded and GCF Galectin-3 and IL-1β total amounts were measured by ELISA. Receiver operating characteristics curve was used for estimating the area under the curve (AUC). Results: Galectin-3 and IL-1β were detected in all participants. Both periodontitis groups had significantly higher GCF Galectin-3 total amounts than periodontally healthy controls (p <0.05). S3GC periodontitis group had also significantly higher GCF Galectin-3 levels than gingivitis group (p <0.05). GCF IL-1β levels in periodontitis groups were higher than gingivitis and periodontally healthy groups (p <0.05). Galectin-3 exhibited an AUC value of 0.89 with 95% sensitivity to discriminate S3GC periodontitis from periodontal health, an AUC value of 0.87 with 80% sensitivity to discriminate S3GC periodontitis versus gingivitis, while an AUC value of 0.85 with 95% sensitivity to discriminate S3GB periodontitis from healthy controls. Conclusions: GCF Galectin-3 levels are involved in the pathogenesis of periodontal diseases. Galectin-3 showed excellent diagnostic performances to discriminate S3GB and S3GC periodontitis from periodontal health and gingivitis. Clinical relevance: The present findings suggest that GCF Galectin-3 levels may be useful in the diagnosis of the periodontal diseases. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
dc.identifier.DOI-ID10.1007/s00784-023-04991-7
dc.identifier.issn14326981
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11949
dc.language.isoEnglish
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.subjectChronic Periodontitis
dc.subjectGalectin 3
dc.subjectGingival Crevicular Fluid
dc.subjectGingivitis
dc.subjectHumans
dc.subjectInterleukin-1beta
dc.subjectgalectin 3
dc.subjectinterleukin 1beta
dc.subjectchronic periodontitis
dc.subjectgingivitis
dc.subjecthuman
dc.titleGingival crevicular fluid galectin-3 and interleukin-1 beta levels in stage 3 periodontitis with grade B and C
dc.typeArticle

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