Serum osteocalcin levels in hyperthyroidism before and after antithyroid therapy

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dc.contributor.authorBarsal G.
dc.contributor.authorTaneli F.
dc.contributor.authorAtay A.
dc.contributor.authorHekimsoy Z.
dc.contributor.authorErciyas F.
dc.date.accessioned2024-07-22T08:24:21Z
dc.date.available2024-07-22T08:24:21Z
dc.date.issued2004
dc.description.abstractHyperthyroidism is characterized by accelerated bone turnover, caused from direct stimulation of bone cells by increased thyroid hormones. In this study, we aimed to investigate serum osteocalcin levels as a bone formation marker, before antithyroid (propylthiouracil) therapy at hyperthyroid stage and after antithyroid therapy at euthyroid stage of the patients. Twenty four hyperthyroid patients (18 females, 6 males) and 20 (13 females, 7 males) healthy controls were included into this study. Blood and urine samples were taken before medical treatment at hyperthyroid state, and after the antithyroid therapy until the patients reached the euthyroid state. Serum alkaline phosphatase, osteocalcin, calcium, phosphorus, Free T3, Free T4, TSH and urine calcium/creatinine levels were assessed. We found a significant decrease in serum osteocalcin (p=0.006), urinary calcium/creatinine (p=0.004), and serum phosphorus (p=0.038) levels in euthyroid state in comparison to hyperthyroid state. The increases in serum bone formation marker osteocalcin and bone resorption marker urinary calcium/creatinine levels in hyperthyroid state compared to euthyroid state in our study confirmed that hyperthyroid patients have high bone turnover. We conclude that, hyperthyroid patients has high bone turnover of formation and resorption even after attainment of euthyroidism. Osteocalcin and urine calcium/creatinine are sensitive markers in documenting bone remodeling during treatment of hyperthyroidism. © 2004 Tohoku University Medical Press.
dc.identifier.DOI-ID10.1620/tjem.203.183
dc.identifier.issn00408727
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19944
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAlkaline Phosphatase
dc.subjectAntithyroid Agents
dc.subjectBiological Markers
dc.subjectBone Resorption
dc.subjectCalcium
dc.subjectCase-Control Studies
dc.subjectCreatinine
dc.subjectFemale
dc.subjectHumans
dc.subjectHyperthyroidism
dc.subjectMale
dc.subjectOsteocalcin
dc.subjectPhosphorus
dc.subjectThyrotropin
dc.subjectThyroxine
dc.subjectTriiodothyronine
dc.subjectalkaline phosphatase
dc.subjectantithyroid agent
dc.subjectbiochemical marker
dc.subjectcalcium ion
dc.subjectcreatinine
dc.subjectliothyronine
dc.subjectosteocalcin
dc.subjectphosphorus
dc.subjectpropylthiouracil
dc.subjectthyrotropin
dc.subjectthyroxine
dc.subjectadult
dc.subjectaged
dc.subjectalkaline phosphatase blood level
dc.subjectarticle
dc.subjectblood sampling
dc.subjectbone remodeling
dc.subjectbone turnover
dc.subjectcalcium blood level
dc.subjectcalcium urine level
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcreatinine urine level
dc.subjectdisease association
dc.subjectdisease marker
dc.subjecteuthyroidism
dc.subjectfemale
dc.subjectfree liothyronine index
dc.subjectfree thyroxine index
dc.subjecthuman
dc.subjecthyperthyroidism
dc.subjectmale
dc.subjectmedical documentation
dc.subjectossification
dc.subjectosteolysis
dc.subjectosteoporosis
dc.subjectphosphate blood level
dc.subjectprotein blood level
dc.subjectsensitivity and specificity
dc.subjectstatistical significance
dc.subjectthyrotropin blood level
dc.subjecturinalysis
dc.titleSerum osteocalcin levels in hyperthyroidism before and after antithyroid therapy
dc.typeArticle

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