Myocardial performance after successful intervention for native aortic coarctation

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dc.contributor.authorTavli V.
dc.contributor.authorSaritas T.
dc.contributor.authorGuven B.
dc.contributor.authorOkur F.
dc.contributor.authorSaylan B.C.
dc.contributor.authorTavli T.
dc.contributor.authorUyanik B.S.
dc.contributor.authorAri Z.
dc.contributor.authorIsbilen B.
dc.date.accessioned2024-07-22T08:21:05Z
dc.date.available2024-07-22T08:21:05Z
dc.date.issued2010
dc.description.abstractCoarctation of the aorta is associated with increased risk for hypertension in adulthood, despite successful repair. The intrinsic mechanisms underscoring hypertension and left ventricular performance in these patients, however, remains to be determined. Our objective was to evaluate left ventricular performance by means of echocardiographic and biochemical parameters at midterm follow-up in normotensive children who have had undergone successful surgical or catheter interventional treatment of coarctation with a residual gradient of less than 20 mmHg at rest. We studied prospectively 14 patients with native aortic coarctation who underwent surgery or balloon angioplasty, the cohort made up of equal numbers of boys and girls, and having a mean age of 8.5 plus or minus 4 years. We also studied 30 age-matched healthy subjects, measuring mitral inflow pulsed wave signals, isovolumic relaxation and contraction times, myocardial performance index parameters, and levels of B-type natriuretic peptide and endothelin-1 in both groups. We found no differences in systolic blood pressure at rest between the patients and their controls. The ventricular septal diastolic dimensions, left ventricular posterior wall dimensions, mitral valve E wave, deceleration time, isovolumic relaxation time, isovolumic contraction time and myocardial performance index were all significantly increased in the patients. Levels of plasma B-type natriuretic peptide and endothelin-1 were also significantly higher in the patients when compared to the control group. We conclude that aortic coarctation is a chronic disease characterized by persistency of myocardial and vascular alterations. The elevated levels of plasma b-type natriuretic peptide and endothelin-1 may be indicative of late onset hypertension after successful treatment of native coarctation in early childhood. © Cambridge University Press 2010.
dc.identifier.DOI-ID10.1017/S1047951109991259
dc.identifier.issn14671107
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18459
dc.language.isoEnglish
dc.subjectAdolescent
dc.subjectAngioplasty, Balloon
dc.subjectAortic Coarctation
dc.subjectBiological Markers
dc.subjectBlood Pressure Determination
dc.subjectCardiac Surgical Procedures
dc.subjectChild
dc.subjectDiastole
dc.subjectEchocardiography, Doppler
dc.subjectEndothelin-1
dc.subjectEndothelium, Vascular
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHeart Catheterization
dc.subjectHeart Function Tests
dc.subjectHumans
dc.subjectHypertrophy, Left Ventricular
dc.subjectMale
dc.subjectMyocardial Contraction
dc.subjectNatriuretic Peptide, Brain
dc.subjectObserver Variation
dc.subjectProbability
dc.subjectProspective Studies
dc.subjectTime Factors
dc.subjectTreatment Outcome
dc.subjectamino terminal pro brain natriuretic peptide
dc.subjectendothelin 1
dc.subjectaorta coarctation
dc.subjectarticle
dc.subjectblood level
dc.subjectcardiovascular parameters
dc.subjectchild
dc.subjectclinical article
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectechocardiography
dc.subjectfemale
dc.subjectfollow up
dc.subjectheart catheterization
dc.subjectheart contraction
dc.subjectheart left ventricle ejection fraction
dc.subjectheart left ventricle performance
dc.subjectheart left ventricle relaxation
dc.subjectheart left ventricle volume
dc.subjectheart left ventricle wall
dc.subjectheart muscle relaxation
dc.subjecthuman
dc.subjectmale
dc.subjectmitral valve
dc.subjectpercutaneous transluminal angioplasty
dc.subjectpulse wave
dc.subjectrandomized controlled trial
dc.subjectschool child
dc.subjectsystolic blood pressure
dc.titleMyocardial performance after successful intervention for native aortic coarctation
dc.typeArticle

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