Cold pressed Pinus halepensis Mill. seed oil for potential health applications: Analgesic, anti-inflammatory effects, and assessment of inflammatory mediators by RT-qPCR in skin wound healing

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dc.contributor.authorAit Atmane S.
dc.contributor.authorBatır M.B.
dc.contributor.authorÖzbek Z.A.
dc.contributor.authorErgönül P.G.
dc.contributor.authorBalcan E.
dc.contributor.authorAit Eldjoudi D.
dc.contributor.authorÖzkale E.
dc.contributor.authorBribi N.
dc.contributor.authorKhettal B.
dc.date.accessioned2024-07-22T08:01:38Z
dc.date.available2024-07-22T08:01:38Z
dc.date.issued2024
dc.description.abstractEthnopharmacological relevance: Pinus halepensis Mill. seed (Pinaceae), commonly known as “Zgougou,” is widely consumed in the Mediterranean region and has long been used to treat diseases including bronchitis, rheumatism, infection, and inflammation. Aim of the study: The present study was focused on the investigation of some pharmacological activities, such as analgesic, anti-inflammatory, and wound healing effects, of cold-pressed oil of Pinus halepensis Mill. seed (COPHS). Materials and methods: The fixed oil of Pinus halepensis seed was extracted by a cold pressing process. The analgesic activity of COPHS was examined by acetic acid and formalin-induced contortion and pain tests. The anti-inflammatory effects were evaluated in carrageenan and formalin induced paw and ear edema models. Wound healing potential was assessed on an experimental skin wound, and the expression levels of inflammation mediators were determined by RT-qPCR in skin wound healing. Results: The results showed analgesic efficacy through significant inhibition of abdominal cramps (59.15%) and pain (75.91%). In addition, this oil exerted an anti-inflammatory effect by inhibiting ear (62.25%) and paw (70.00%) edema. The COPHS stimulated wound contraction in experimental skin wound healing with a contraction rate of 89.23% with notable reduction of TNF-α and NF-kB expression levels in the treated groups. Conclusions: This study provided for the first time the pharmacological profile, particularly the analgesic, anti-inflammatory, and healing effects, of fixed oil extracted by cold pressing from the seed of Pinus halepensis Mill. © 2023 Elsevier B.V.
dc.identifier.DOI-ID10.1016/j.jep.2023.117157
dc.identifier.issn03788741
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11529
dc.language.isoEnglish
dc.publisherElsevier Ireland Ltd
dc.subjectAnalgesics
dc.subjectAnti-Inflammatory Agents
dc.subjectCarrageenan
dc.subjectEdema
dc.subjectFormaldehyde
dc.subjectInflammation Mediators
dc.subjectPain
dc.subjectPinus
dc.subjectPlant Extracts
dc.subjectPlant Oils
dc.subjectSeeds
dc.subjectWound Healing
dc.subjectanalgesic agent
dc.subjectantiinflammatory agent
dc.subjectasiaticoside
dc.subjectcold pressed pinus halepensis mill. seed oil
dc.subjectcyclooxygenase 1
dc.subjectcyclooxygenase 2
dc.subjectdiclofenac
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectindometacin
dc.subjectinterleukin 6
dc.subjectketamine
dc.subjectprostaglandin synthase
dc.subjectprostaglandin synthase 1
dc.subjectprostaglandin synthase 2
dc.subjectsalicylic acid
dc.subjecttumor necrosis factor
dc.subjectunclassified drug
dc.subjectvegetable oil
dc.subjectwound healing promoting agent
dc.subjectxylazine
dc.subjectxylene
dc.subjectanalgesic agent
dc.subjectantiinflammatory agent
dc.subjectautacoid
dc.subjectcarrageenan
dc.subjectformaldehyde
dc.subjectplant extract
dc.subjectvegetable oil
dc.subjectabdominal cramp
dc.subjectabdominal pain
dc.subjectanalgesic activity
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantiinflammatory activity
dc.subjectArticle
dc.subjectcarrageenan-induced paw edema
dc.subjectcontrolled study
dc.subjectdrug isolation
dc.subjectexperimental ear edema
dc.subjectformalin-induced pain
dc.subjectgene expression level
dc.subjectinflammatory pain
dc.subjectmale
dc.subjectmouse
dc.subjectNF kB signaling
dc.subjectnonhuman
dc.subjectpine
dc.subjectPinus halepensis
dc.subjectplant seed
dc.subjectreal time reverse transcription polymerase chain reaction
dc.subjectskin biopsy
dc.subjectskin injury
dc.subjectSouthern Europe
dc.subjectwound contraction
dc.subjectwound healing
dc.subjectchemistry
dc.subjectedema
dc.subjectmetabolism
dc.subjectpain
dc.subjectplant seed
dc.subjectwound healing
dc.titleCold pressed Pinus halepensis Mill. seed oil for potential health applications: Analgesic, anti-inflammatory effects, and assessment of inflammatory mediators by RT-qPCR in skin wound healing
dc.typeArticle

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