Index depressive episode and antidepressant exposure were associated with illness characteristics of pediatric bipolar disorder

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dc.contributor.authorInal N.
dc.contributor.authorErmis C.
dc.contributor.authorKoc D.
dc.contributor.authorAksoy S.
dc.contributor.authorKaracetin G.
dc.contributor.authorTuncturk M.
dc.contributor.authorEray S.
dc.contributor.authorKarabina B.
dc.contributor.authorFaruk Akca O.
dc.contributor.authorOzgul D.
dc.contributor.authorGunay Kilic B.
dc.contributor.authorCikili Uytun M.
dc.contributor.authorBesenek M.
dc.contributor.authorKavurma C.
dc.contributor.authorBilac O.
dc.contributor.authorGokcen C.
dc.contributor.authorTopal Z.
dc.contributor.authorPercinel Yazıcı I.
dc.contributor.authorSapmaz S.Y.
dc.contributor.authorOzyurt G.
dc.contributor.authorDiler R.S.
dc.date.accessioned2024-07-22T08:04:44Z
dc.date.available2024-07-22T08:04:44Z
dc.date.issued2022
dc.description.abstractObjective: Pediatric bipolar disorder (PBD) is a serious, recurrent disorder leading to severe functional impairment. As a first mood episode, index episode could affect the long-term course of the illness. This study aimed to investigate the clinical characteristics of youth with PBD from our multicenter, nationwide, naturalistic follow-up samples and to identify (i) the effects of index mood episode and (ii) the effect of previous antidepressant treatments on the age at mania onset of PBD. Method: The study sample consisted of 271 youth with BD-I followed by the child and adolescent psychiatry clinics of seven different university hospitals and three research state hospitals, representing six geographic regions across Turkey. All diagnoses were made according to structured interviews, and all data were retrospectively obtained from clinical records by the clinicians. Results: When patients with index depressive/mixed episodes (IDE, n=129) and patients with index (hypo)manic episodes (IME, n=142) were compared, the total number of mood episodes and rapid cycling feature were significantly higher in the IDE group than in the IME group. The Cox regression analysis adjusted for sociodemographic and illness characteristics revealed female adolescents in the IDE group treated with antidepressants were more likely to have an earlier onset of mania (hazard ratio=2.03, 95% confidence interval=1.31–3.12, p=0.001). Conclusion: This is the first large-scale nationwide follow-up study in Turkey that indicated prior antidepressant treatments were associated with an earlier onset of mania in youth, particularly in adolescent females. Larger prospective studies are needed to identify neurodevelopmental processes underlying PBD and initiate prevention approaches. © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
dc.identifier.DOI-ID10.1111/acps.13333
dc.identifier.issn0001690X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12822
dc.language.isoEnglish
dc.publisherJohn Wiley and Sons Inc
dc.subjectAdolescent
dc.subjectAffect
dc.subjectAntidepressive Agents
dc.subjectBipolar Disorder
dc.subjectChild
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectRetrospective Studies
dc.subjectantidepressant agent
dc.subjectaripiprazole
dc.subjectclozapine
dc.subjectlamotrigine
dc.subjectlithium
dc.subjectolanzapine
dc.subjectquetiapine
dc.subjectrisperidone
dc.subjectserotonin uptake inhibitor
dc.subjecttricyclic antidepressant agent
dc.subjectvalproic acid
dc.subjectantidepressant agent
dc.subjectadolescent
dc.subjectadult
dc.subjectanxiety disorder
dc.subjectArticle
dc.subjectattention deficit hyperactivity disorder
dc.subjectbipolar disorder
dc.subjectchild
dc.subjectchild psychiatry
dc.subjectconduct disorder
dc.subjectdepression
dc.subjectdisease association
dc.subjectdisease duration
dc.subjectdrug exposure
dc.subjecteducational status
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjecthypomania
dc.subjectlongitudinal study
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmania
dc.subjectmixed mania and depression
dc.subjectmood change
dc.subjectobsessive compulsive disorder
dc.subjectonset age
dc.subjectpsychopharmacotherapy
dc.subjectretrospective study
dc.subjectsex difference
dc.subjectstructured interview
dc.subjectaffect
dc.subjectbipolar disorder
dc.subjectclinical trial
dc.subjectmulticenter study
dc.titleIndex depressive episode and antidepressant exposure were associated with illness characteristics of pediatric bipolar disorder
dc.typeArticle

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