Sinopulmonary aspergillosis in children with hematological malignancy

Simple item page
dc.contributor.authorGulen H.
dc.contributor.authorErbay A.
dc.contributor.authorGulen F.
dc.contributor.authorKazanci E.
dc.contributor.authorVergin C.
dc.contributor.authorDemir E.
dc.contributor.authorTanac R.
dc.date.accessioned2024-07-22T08:23:25Z
dc.date.available2024-07-22T08:23:25Z
dc.date.issued2006
dc.description.abstractInvasive pulmonary aspergillosis is a serious infectious complication in immunocompromised especially neutropenic patients. Despite improvements in early diagnosis and effective treatment, invasive pulmonary aspergillosis is still a devastating opportunistic infection. These infections also interfere with the anticancer treatment. We report our experience in the diagnosis and therapeutic management of sinopulmonary aspergillosis in 4 children with hematologic malignancy. All patients except the first were neutropenic when sinopulmonary aspergillosis was diagnosed. Clinical signs included fever, cough, respiratory distress, swallowing difficulty, headache, facial pain-edema and hard palate necrosis. Radiodiagnostic methods showed bilateral multiple nodular infiltrations, soft tissue densities filling all the paranasal sinuses, and bronchiectasis. Diagnosis of aspergillosis was established by bronchoalveolar lavage in one case, tissue biopsy, positive sputum and positive cytology, respectively, in the other 3 cases. One patient was treated with liposomal amphotericin B and other 3 cases were treated with liposomal amphotericin B + itraconozole. Outcome was favorable in all cases except the one who died due to respiratory failure. Early diagnosis, appropriate treatment and primary disease status are important factors on prognosis of Aspergillus infections in children with hematological malignancy.
dc.identifier.issn00264946
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19534
dc.language.isoEnglish
dc.subjectAcute Disease
dc.subjectAdolescent
dc.subjectAmphotericin B
dc.subjectAntifungal Agents
dc.subjectAspergillosis
dc.subjectBurkitt Lymphoma
dc.subjectChild
dc.subjectDrug Therapy, Combination
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunocompromised Host
dc.subjectItraconazole
dc.subjectLeukemia, Lymphocytic, Acute
dc.subjectLeukemia, Myeloid
dc.subjectLung Diseases, Fungal
dc.subjectMale
dc.subjectPrognosis
dc.subjectRadiography, Thoracic
dc.subjectTime Factors
dc.subjectTomography, X-Ray Computed
dc.subjectamphotericin B lipid complex
dc.subjectantibiotic agent
dc.subjectcytarabine
dc.subjectitraconazole
dc.subjectmitoxantrone
dc.subjectacute granulocytic leukemia
dc.subjectacute lymphocytic leukemia
dc.subjectadolescent
dc.subjectanamnesis
dc.subjectarticle
dc.subjectAspergillus flavus
dc.subjectbronchiectasis
dc.subjectcase report
dc.subjectchild
dc.subjectclinical feature
dc.subjectfebrile neutropenia
dc.subjectfemale
dc.subjecthematologic malignancy
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectlaboratory test
dc.subjectlobectomy
dc.subjectlung aspergillosis
dc.subjectlung biopsy
dc.subjectlung lavage
dc.subjectmale
dc.subjectnasal biopsy
dc.subjectparanasal sinus disease
dc.subjectphysical examination
dc.subjectprognosis
dc.subjectradiodiagnosis
dc.subjectrespiratory failure
dc.subjectsoft tissue disease
dc.subjectsputum cytodiagnosis
dc.subjecttreatment outcome
dc.titleSinopulmonary aspergillosis in children with hematological malignancy
dc.typeArticle

Files

Collections

Scopus Koleksiyonu