Relationship between circulating IGF-1 levels and traumatic brain injury-induced hippocampal damage and cognitive dysfunction in immature rats

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dc.contributor.authorOzdemir D.
dc.contributor.authorBaykara B.
dc.contributor.authorAksu I.
dc.contributor.authorKiray M.
dc.contributor.authorSisman A.R.
dc.contributor.authorCetin F.
dc.contributor.authorDayi A.
dc.contributor.authorGurpinar T.
dc.contributor.authorUysal N.
dc.contributor.authorArda M.N.
dc.date.accessioned2024-07-22T08:19:36Z
dc.date.available2024-07-22T08:19:36Z
dc.date.issued2012
dc.description.abstractIt is well known that traumatic brain injury (TBI) induces the cognitive dysfunction resulting from hippocampal damage. In the present study, we aimed to assess whether the circulating IGF-I levels are associated with cognition and hippocampal damage in 7-day-old rat pups subjected to contusion injury. Hippocampal damage was examined by cresyl violet staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Spatial memory performance was assessed in the Morris water maze. Serum IGF-1 levels decreased in both early and late period of TBI. Decreased levels of serum IGF-1 were correlated with hippocampal neuron loss and spatial memory deficits. Circulating IGF-1 levels may be predictive of cognitive dysfunction resulted from hippocampal damage following traumatic injury in developing brain. Therapy strategies that increase circulating IGF-1 may be highly promising for preventing the unfavorable outcomes of traumatic damage in young children. © 2011 Elsevier Ireland Ltd.
dc.identifier.DOI-ID10.1016/j.neulet.2011.11.059
dc.identifier.issn18727972
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17762
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectBrain Injuries
dc.subjectCognition
dc.subjectCognition Disorders
dc.subjectHippocampus
dc.subjectInsulin-Like Growth Factor I
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectStatistics as Topic
dc.subjectsomatomedin C
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectbrain contusion
dc.subjectbrain damage
dc.subjectbrain development
dc.subjectbrain nerve cell
dc.subjectcognitive defect
dc.subjectcontrolled study
dc.subjectdentate gyrus
dc.subjectescape behavior
dc.subjecthippocampus
dc.subjectlatent period
dc.subjectleft hemisphere
dc.subjectmaze test
dc.subjectmemory disorder
dc.subjectnerve cell necrosis
dc.subjectnick end labeling
dc.subjectnonhuman
dc.subjectpredictive value
dc.subjectprefrontal cortex
dc.subjectpriority journal
dc.subjectprotein blood level
dc.subjectrat
dc.subjectright hemisphere
dc.subjectspatial memory
dc.subjecttask performance
dc.subjecttraumatic brain injury
dc.titleRelationship between circulating IGF-1 levels and traumatic brain injury-induced hippocampal damage and cognitive dysfunction in immature rats
dc.typeArticle

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