Bladder Function Recovery in Rats With Traumatic Spinal Cord Injury After Transplantation of Neuronal-Glial Restricted Precursors or Bone Marrow Stromal Cells

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dc.contributor.authorTemeltas G.
dc.contributor.authorDagci T.
dc.contributor.authorKurt F.
dc.contributor.authorEvren V.
dc.contributor.authorTuglu I.
dc.date.accessioned2024-07-22T08:21:45Z
dc.date.available2024-07-22T08:21:45Z
dc.date.issued2009
dc.description.abstractPurpose: We investigated functional recovery of the lower urinary system in rats with spinal cord injury after transplanting neuronal restricted precursors/glial restricted precursors or neural cells derived from bone marrow stromal cells into the injured area of the spinal cord. Materials and Methods: A total of 30 rats underwent experimentation in 4 groups, including group 1-sham operation, group 2-spinal cord injury plus neuronal restricted precursor/glial restricted precursor transplantation, group 3-spinal cord injury plus bone marrow stromal cell transplantation and group 4-spinal cord injury control. All rats in the 4 groups were investigated urodynamically and sacrificed on day 28 after transplantation. The cells transplanted into the injured spinal cord underwent histological investigation. Results: Transplanted cells (neuronal and glial restricted precursors, and bone marrow stromal cells) were found to maintain a presence in the injured spinal cord area. Baseline pressure, maximum capacity, mean uninhibited contraction amplitude, mean voiding pressure, voided volume and post-void residual volume were significantly better in groups 2 and 3 than in group 4, while baseline pressure in group 2 was better than that in group 3. We found no significant difference among the groups according to mean uninhibited contraction frequency. Conclusions: Although neuronal/glial restricted precursor transplanted rats seemed to have more improvement, all rats in groups 2 and 3 showed some significant improvement in lower urinary system function. On the other hand, the level of this improvement was far from complete functional recovery. © 2009 American Urological Association.
dc.identifier.DOI-ID10.1016/j.juro.2009.01.093
dc.identifier.issn00225347
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18765
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectBone Marrow Transplantation
dc.subjectNeuroglia
dc.subjectNeurons
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectRecovery of Function
dc.subjectSpinal Cord Injuries
dc.subjectStem Cell Transplantation
dc.subjectStromal Cells
dc.subjectUrinary Bladder
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarticle
dc.subjectbladder function
dc.subjectcell transplantation
dc.subjectcontrolled study
dc.subjectglia cell
dc.subjectnerve cell
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectresidual urine
dc.subjectsham procedure
dc.subjectspinal cord injury
dc.subjecturodynamics
dc.titleBladder Function Recovery in Rats With Traumatic Spinal Cord Injury After Transplantation of Neuronal-Glial Restricted Precursors or Bone Marrow Stromal Cells
dc.typeArticle

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