Role of increased mean platelet volume (MPV) and decreased MPV/platelet count ratio as poor prognostic factors in lung cancer
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Date
2018
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Abstract
Objectives: In this study, they investigated whether mean thrombocyte volume (MPV) and MPV/platelet count ratio have a prognostic significance in advanced NSCLC or not. Methods: A total of 496 NSCLC patients at stage IIIB/IV and did not meet exclusion criteria were included in the study. The demographic features (age, gender, smoking habit), clinical characteristics (performance status, weight loss, disease stage, first-line treatment regimen), laboratory tests (levels of hemoglobin, lactate dehydrogenase and calcium as well as MPV, MPV/platelet count ratio and counts of white blood cell, platelet), and histological features (histologic type, tumor grade) were recorded. Results: The MPV levels of all patients were determined as 10.2 {plus minus} 3.4 (range, 6.4-14.1 fL). With ROC curve analysis, the MPV/PC ratio was associated with a sensitivity of 67.8% and a specificity of 84.8% at a cutoff value of 0.47424 for presence of brain metastasis at the time of diagnosis. Univariate analysis showed that OS was significantly shorter in the group with an increased MPV level than in the other group (median OS time 6.8 months vs. 11.5 months, log-rank, P =.032). Multivariate analysis confirmed that an increased MPV level was an independent poor prognostic factor for OS (HR: 1.704, 95% CI: 1.274-3.415, P =.014). Conclusions: Unlike results of previous studies, the study showed that increased MPV was an important prognostic factor in patients with NSCLC. Hence, an increased MPV level may be used as a prognostic biomarker to estimate for poor overall survival in patients with NSCLC. © 2017 John Wiley & Sons Ltd
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Aged , Biomarkers , Blood Platelets , Carcinoma, Non-Small-Cell Lung , Female , Humans , Karnofsky Performance Status , L-Lactate Dehydrogenase , Lung Neoplasms , Male , Mean Platelet Volume , Middle Aged , Neoplasm Staging , Platelet Count , Prognosis , Smoking , Survival Analysis , calcium , hemoglobin , lactate dehydrogenase , biological marker , lactate dehydrogenase , adult , age , Article , body weight loss , brain metastasis , calcium blood level , cancer chemotherapy , cancer grading , cancer prognosis , cancer staging , cancer survival , controlled study , diagnostic test accuracy study , female , gender , hemoglobin blood level , histopathology , human , lactate dehydrogenase blood level , leukocyte count , major clinical study , male , mean platelet volume , medical record review , middle aged , non small cell lung cancer , overall survival , platelet count , priority journal , progression free survival , receiver operating characteristic , retrospective study , sensitivity and specificity , smoking habit , aged , blood , epidemiology , Karnofsky Performance Status , lung tumor , mean platelet volume , mortality , non small cell lung cancer , pathology , platelet count , procedures , prognosis , smoking , statistics and numerical data , survival analysis , thrombocyte